Zobrazeno 1 - 10
of 29
pro vyhledávání: ''
Autor:
Abdallah Hamze, Marie-Edith Rafestin-Oblin, Jean-Daniel Brion, Jérôme Fagart, Abdellatif Tikad, Michel Fay, Mouad Alami, Nathalie Chabbert-Buffet, Hugues Loosfelt, Larbi Amazit, Geri Meduri, Marc Lombès, Junaid Ali Khan
Publikováno v:
Molecular Endocrinology. 27:909-924
Currently available progesterone (P4) receptor (PR) antagonists, such as mifepristone (RU486), lack specificity and display partial agonist properties, leading to potential drawbacks in their clinical use. Recent x-ray crystallographic studies have i
Autor:
Sujit S. Nair, Darrell W Brann, Dujin Zhou, Rajib Rajhans, Valerie Cortez, Hareesh B. Nair, Ratna K. Vadlamudi, Nameer B. Kirma, Alan E.C. Holden, Kijima Ikuko, Rajeshwar Rao Tekmal, Shiuan Chen
Publikováno v:
Molecular Endocrinology. 22:649-664
In situ estrogen synthesis is implicated in tumor cell proliferation through autocrine or paracrine mechanisms especially in postmenopausal women. Several recent studies demonstrated activity of aromatase, an enzyme that plays a critical role in estr
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Autor:
Helmut Grasberger, Marc Abramowicz, Paule LeFrancois, Samuel Refetoff, Usanee Ringkananont, Gilbert Vassart
Publikováno v:
Molecular Endocrinology. 19:1779-1791
Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family. The
Autor:
Sophie Giorgetti-Peraldi, Marie-Noëlle Monthouël-Kartmann, Joseph Murdaca, Emmanuel Van Obberghen, Caroline Treins
Publikováno v:
Molecular Endocrinology. 19:1304-1317
Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-inde
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav
Autor:
Minoru Asada, Yoel Sadovsky, Louis J. Muglia, Yoshihiko Nagai, Thomas J. Hudson, Kathleen E. Bethin, Robert Sladek
Publikováno v:
Molecular Endocrinology. 17:1454-1469
Improved care of infants born prematurely has increased their survival. However, the incidence of preterm labor has not changed. To understand the processes involved in preterm labor, we used oligonucleotide microarrays to study gene expression in mu
Autor:
Donald B. DeFranco
Publikováno v:
Molecular Endocrinology. 16:1449-1455
Steroid hormone receptors exert much of their effects on cellular physiology through regulating the rate of transcription from unique target genes. Much has been learned about the actions of steroid hormone receptors at regulated promoters through mo
Autor:
Olivier Goupille, Andrew Ziemiecki, Wolfgang Doppler, Claudia Soratroi, Martin Tonko, Sibylle Tonko-Geymayer, Charles H. Streuli, Reinhard Kofler, Akihiko Yoshimura
Publikováno v:
Molecular Endocrinology. 16:1680-1695
The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal tr