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Autor:
Ryoichi Takayanagi, Akiyoshi Fukamizu, Hajime Nawata, Kiminobu Goto, Masayuki Saitoh, Arihiro Tomura, Toshihiko Yanase
Publikováno v:
Molecular Endocrinology. 16:694-706
To clarify the physiological significance of the intranuclear speckled distribution, or foci formation, of liganded steroid receptors, the subnuclear distribution of green (GFP), yellow (YFP), and cyan (CFP) fluorescent protein-tagged receptors and c
Autor:
Marie Pierre Gaub, Huib A.P. Pols, Janet L. Stein, J.P.T.M. van Leeuwen, Gary S. Stein, H. F. Deluca, J. Prahl, Jan C. Birkenhäger, A. Staal, A. J. Van Wijnen, J. B. Lian
Publikováno v:
Scopus-Elsevier
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs). Sequence
Autor:
Joe S. Mymryk, Trevor K. Archer
Publikováno v:
Molecular Endocrinology. 9:1825-1834
Steroid hormones act via a group of high affinity receptors that regulate transcription by binding to hormone response elements located in the promoters of hormone-inducible genes. Our understanding of these processes has been greatly enhanced by the
Autor:
Michael R. Stallcup, Janis L. Corey
Publikováno v:
Molecular Endocrinology. 6:450-458
Mouse lymphoma cell line W7MG1 is stably infected with mouse mammary tumor virus and produces the viral envelope glycoprotein precursor Pr74, but the mature envelope proteins gp52 and gp33, which are derived from Pr74 by posttranslational processing,
Publikováno v:
Molecular Endocrinology. 4:1144-1152
The Y1 mouse adrenocortical tumor cell line retains the ability to synthesize and secrete steroids, but does not express steroid 21-hydroxylase (C21) and, therefore, does not produce 21-hydroxylated steroids. In this investigation the mechanisms unde
Publikováno v:
Molecular Endocrinology. 3:295-304
Since sex steroid hormones and growth factors are known to modulate the proliferation of breast tumors, we have studied the effects of estrogen and progestin, their antagonists, and growth factors on the regulation of estrogen receptor (ER) mRNA and
Publikováno v:
Molecular Endocrinology. 2:1256-1264
The mechanism of ligand-induced (homologous) down-regulation of the glucocorticoid receptor (GR) has been studied. Dexamethasone caused a down-regulation of the levels of GR mRNA and protein both in hepatoma tissue culture cells and rat liver in vivo
Publikováno v:
Molecular Endocrinology. 3:1270-1278
Progesterone receptor-containing T47D human breast cancer cells are responsive to progestins but fail to respond to other steroid hormones, in particular dexamethasone, because they have no measurable levels of receptors for estrogens, androgens, or
Publikováno v:
Molecular Endocrinology. 1:933-941
The effect of the glucocorticoid dexamethasone on the production and degradation of rat GH (rGH) cytoplasmic mRNA was studied in cultured rat pituitary tumor (GC) cells. The incorporation of [3H]uridine into both rGH cytoplasmic mRNA and the pyrimidi
Autor:
Sophia Y. Tsai, Jonathan F. Elliston, Dean P. Edwards, Ming-Jer Tsai, Bert W. O'Malley, Milan K. Bagchi
Publikováno v:
Molecular Endocrinology. 2:1221-1229
We investigated the requirement of steroid hormone for the specific binding of progesterone receptor to its cognate progesterone responsive element (PRE) in cell-free experiments. We prepared unfractionated nuclear extracts from human breast cancer (