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Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Publikováno v:
Molecular Endocrinology. 25:611-620
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epitheli
Autor:
Shuyun Rao, Joanne M. Faysal, Carol A. Maiorino, Wayne Balkan, Leah S. Lyons, Kerry L. Burnstein
Publikováno v:
Molecular Endocrinology. 22:597-608
Prostate cancer invariably recurs after androgen deprivation therapy. Growth of this recurrent/androgen-independent form of prostate cancer may be due to increased androgen receptor (AR) transcriptional activity in the absence of androgen. This ligan
Autor:
Sujit S. Nair, Darrell W Brann, Dujin Zhou, Rajib Rajhans, Valerie Cortez, Hareesh B. Nair, Ratna K. Vadlamudi, Nameer B. Kirma, Alan E.C. Holden, Kijima Ikuko, Rajeshwar Rao Tekmal, Shiuan Chen
Publikováno v:
Molecular Endocrinology. 22:649-664
In situ estrogen synthesis is implicated in tumor cell proliferation through autocrine or paracrine mechanisms especially in postmenopausal women. Several recent studies demonstrated activity of aromatase, an enzyme that plays a critical role in estr
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Publikováno v:
Molecular Endocrinology. 20:844-856
We have identified Kruppel-like factor 7 (KLF7) as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of KLF7 in the pathogenesis of type 2 diabetes, we examined the functional roles of KLF7 in var
Autor:
Sophie Giorgetti-Peraldi, Marie-Noëlle Monthouël-Kartmann, Joseph Murdaca, Emmanuel Van Obberghen, Caroline Treins
Publikováno v:
Molecular Endocrinology. 19:1304-1317
Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-inde
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Publikováno v:
Molecular Endocrinology. 19:312-326
We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3′-k
Publikováno v:
Molecular Endocrinology. 18:1670-1686
Previous studies have shown that the synthesis and stability of milk protein mRNAs are regulated by lactogenic hormones. We demonstrate here in cultured mouse mammary epithelial cells (CID 9) that insulin plus prolactin also synergistically increases