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Autor:
Ming Ding, Tomomi Miyamoto, Paul S. Kim, Ji-Ming Cheng, Takashi Agui, Sen-ichi Furudate, Cha-Gyun Jung, Bailing Li, Shekar Menon
Publikováno v:
Molecular Endocrinology. 14:1944-1953
A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus-Elsevier
instname
Scopus-Elsevier
Diabetes in the rat is associated with poor growth and decreased GH in the pituitary. In this study we have examined whether this reduction reflects an impairment of GH gene expression. Diabetes was induced by the administration of streptozotocin (7
Autor:
Danielle Naville, Judith R. Head, J. Ian Mason, Diane S. Keeney, Graham Jenkin, Barbara A. Murry
Publikováno v:
Molecular Endocrinology. 5:1090-1100
In the steroidogenic pathways present in the gonads and adrenal cortex, 3 beta-hydroxysteroid dehydrogenase isomerase (3 beta HSD) is a key enzyme which controls the formation of delta 4-3-ketosteroids from delta 5-3 beta-hydroxysteroids. Herein, we
Publikováno v:
Molecular Endocrinology. 4:1655-1660
We evaluated the role insulin plays in the regulation of hepatic S14 gene transcription using the streptozotocin-induced diabetic rat model. Nuclear run-on activity and mRNAS14 levels were reduced by more than 85% in diabetic rats compared to those i
Publikováno v:
Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pitu
Autor:
J. Schwander, Christoph Schmid, Ernst Rudolf Prof Dr Froesch, J Zapf, Peter J. Meier, J.-L. Mary, M. Boni-Schnetzler, B. Zimmerli
Publikováno v:
Molecular Endocrinology. 4:1320-1326
The goal of this study was to find out whether GH or insulin regulate the mRNA expression of the fetal binding protein of insulin-like growth factor (IGFBP-2). Primary hepatocytes from adult rats were used as a test system. IGFBP-2 mRNA was abundant
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Publikováno v:
Molecular Endocrinology. 4:1386-1398
To investigate the potential role(s) of the insulin-like growth factors (IGFs) in embryogenesis, we have used in situ hybridization histochemistry to localize mRNAs for IGF-I, IGF-II, and the type I IGF receptor during an early period in rat embryoni
Publikováno v:
Molecular Endocrinology. 4:1199-1204
The low mol wt insulin-like growth factor-binding protein (IGFBP-1) originally isolated from amniotic fluid has been considered to be GH independent. In this report we have examined the effect of GH on hepatic IGFBP-1 expression in the hypophysectomi
Autor:
Maureen K. Steed, John A. Robertson, Timothy J. J. Wood, Jan-Ake Gustafsson, Lars Arne Haldosén
Publikováno v:
Molecular Endocrinology. 4:1235-1239
The female-specific expression of the rat liver PRL receptor (PRL-R) gene was investigated by Northern analysis of hypophysectomized rats after two alternative human GH treatments that were to mimic either 1) the continuous female-specific or 2) the