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Autor:
Darawan Pinthong, Supachoke Mangmool, Sarawuth Phosri, Motohiro Nishida, Tsukasa Shimauchi, Tananat Denkaew, Warisara Parichatikanond
Publikováno v:
Molecular Endocrinology. 30:118-132
Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pat
Publikováno v:
Molecular Endocrinology. 29:682-692
Type 2 diabetes mellitus (T2DM) is characterized by pancreatic islet failure due to loss of β-cell secretory function and mass. Studies have identified a link between a variance in the gene encoding melatonin (MT) receptor 2, T2DM, and impaired insu
Autor:
Adolfo Garcia-Ocaña, Ann Marie Segal, Juan Carlos Alvarez-Perez, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 29 (2015): 542–547. doi:10.1210/me.2014-1273
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
Human islet ?-cells exploit an autocrine dopamine (DA)-mediated inhibitory circuit to regulate insulin secretion. ?-Cells also express the DA active transporter and the large neutral amino acid transporter heterodimer enabling them to import circulat
Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Autor:
Yuko Ishido, Aya Yoshihara, Donald F. Sellitti, Yuqian Luo, Akira Kawashima, Takeshi Akama, Akito Tanoue, Kazuaki Nakamura, Kazunari Tanigawa, Koichi Suzuki
Publikováno v:
Molecular Endocrinology. 28:368-379
Thyroglobulin (Tg), stored in the follicular lumen, has also been shown recently to perform two unexpected roles: as an autocrine negative-feedback suppressor of thyroid function in the presence of TSH and as a potent inducer of thyroid cell growth i
Publikováno v:
Molecular Endocrinology. 27:162-171
The increased insulin secretory burden placed on pancreatic β-cells during obesity and insulin resistance can ultimately lead to β-cell dysfunction and death and the development of type 2 diabetes. Mitogen-inducible gene 6 (Mig6) is a cellular stre
Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Publikováno v:
Molecular Endocrinology. 26:1339-1355
The proglucagon gene is expressed not only in the pancreas and intestine but also in the hypothalamus. Proglucagon-derived peptides have emerged as potential regulators of energy homeostasis. Whether leptin, insulin, or cAMP activation controls progl
Autor:
Ulrike Henrion, Martin Fraunholz, Behnam Hessabi, Robert Smail Jack, Annett Ostmann, Anke Karkour, Meike Dahlhaus, Piotr Grabarczyk, Reinhard Walther, Gabriele Wolf, Bernd Giese
Publikováno v:
Molecular Endocrinology. 24:2331-2342
The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element. To analyze the role of
Publikováno v:
Molecular Endocrinology. 24:1423-1433
Most people with type 2 diabetes (T2D) have reduced beta-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high gluco