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Publikováno v:
Molecular Endocrinology. 5:897-904
In the mouse insulin is first detected on embryonic day 12 (e12) in a subpopulation of the cells that on e10 start to produce glucagon. During the continued embryonic development, the number of cells that coexpress the two hormones is gradually decre
Publikováno v:
Molecular Endocrinology. 5:890-896
Insulin-like growth factor-I (IGF-I) attenuates GH gene expression by a receptor-mediated mechanism in pituitary cells. We, therefore, isolated neomycin-resistant stable GC cell transfectants over-expressing human IGF-I receptor cDNA (IGFIR-cDNA) clo
Autor:
Donald A. McClain
Publikováno v:
Molecular Endocrinology. 5:734-739
The human insulin receptor (hIR) is expressed in two variant forms that are generated by tissue-specific alternative splicing of the 11th exon of the IR gene. This leads to receptors that differ in their affinities for insulin based on the absence (h
Autor:
Prabha A. Ram, David J. Waxman
Publikováno v:
Molecular Endocrinology. 5:13-20
Studies carried out in hypophysectomized adult rats have demonstrated that both thyroid hormone and GH can suppress hepatic expression of the steroid 6 beta-hydroxylase P450 2a (IIIA2). The present study further characterizes the influence of thyroid
Publikováno v:
Molecular Endocrinology. 4:1655-1660
We evaluated the role insulin plays in the regulation of hepatic S14 gene transcription using the streptozotocin-induced diabetic rat model. Nuclear run-on activity and mRNAS14 levels were reduced by more than 85% in diabetic rats compared to those i
Publikováno v:
Molecular Endocrinology. 4:1438-1443
When a human fetal muscle cDNA library was screened with the human thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA. The sequence of the insert was 2498 basepairs, with an open reading frame of 1794 basepair
Publikováno v:
Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pitu
Autor:
J. Schwander, Christoph Schmid, Ernst Rudolf Prof Dr Froesch, J Zapf, Peter J. Meier, J.-L. Mary, M. Boni-Schnetzler, B. Zimmerli
Publikováno v:
Molecular Endocrinology. 4:1320-1326
The goal of this study was to find out whether GH or insulin regulate the mRNA expression of the fetal binding protein of insulin-like growth factor (IGFBP-2). Primary hepatocytes from adult rats were used as a test system. IGFBP-2 mRNA was abundant
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Publikováno v:
Molecular Endocrinology. 4:1386-1398
To investigate the potential role(s) of the insulin-like growth factors (IGFs) in embryogenesis, we have used in situ hybridization histochemistry to localize mRNAs for IGF-I, IGF-II, and the type I IGF receptor during an early period in rat embryoni