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Publikováno v:
Molecular Endocrinology. 15:1993-2009
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expre
Autor:
Indrani C. Bagchi, Padmaja Ganapathy, Xueping Xu, Dahu Chen, Milan K. Bagchi, Li-Ji Zhu, Quanxi Li
Publikováno v:
Molecular Endocrinology. 13:993-1004
The steroid hormone estrogen profoundly influences the early events in the uterus leading to embryo implantation. It is thought that estrogen triggers the expression of a unique set of genes in the preimplantation endometrium that in turn control imp
Autor:
Christian H. Wetzel, Florian Holsboer, Gerhard Rammes, Rainer Rupprecht, Elmar Pestel, Walter Zieglgänsberger, B. Hermann, Christian Behl
Publikováno v:
Scopus-Elsevier
Steroid hormone action involves binding to cognate intracellular receptors that, in turn, bind to respective response elements and thus modulate gene expression. The present study shows that the gonadal steroids, 17beta-estradiol and progesterone, ma
Publikováno v:
Molecular Endocrinology. 11:801-811
A combination of a knockout mouse model, tissue transplantation, and gene expression analysis has been used to investigate the role of steroid hormones in mammary gland development. Mouse mammary gland development was examined in progesterone recepto
Autor:
Christina A. Harrington, Mindy F. Rosenthal, Dona M. Chikaraishi, Joan I. Morrell, Joseph T. McCabe, Donald W. Pfaff
Publikováno v:
Molecular Endocrinology. 3:1426-1433
The dopamine-producing neurons of the tuberoinfundibular region are known targets of estrogen and progesterone, and are of considerable neuroendocrine importance. To determine the anatomical distribution, and number of cells that contain tyrosine hyd
Publikováno v:
Molecular Endocrinology. 3:1270-1278
Progesterone receptor-containing T47D human breast cancer cells are responsive to progestins but fail to respond to other steroid hormones, in particular dexamethasone, because they have no measurable levels of receptors for estrogens, androgens, or
Publikováno v:
Molecular Endocrinology. 3:356-362
Previous analyses have indicated that steroid hormone receptors undergo an allosteric change in structure upon binding by the steroid ligand. This structural change was envisioned as an intramolecular unmasking of the protein's DNA-binding domain, th
Autor:
Sophia Y. Tsai, Jonathan F. Elliston, Dean P. Edwards, Ming-Jer Tsai, Bert W. O'Malley, Milan K. Bagchi
Publikováno v:
Molecular Endocrinology. 2:1221-1229
We investigated the requirement of steroid hormone for the specific binding of progesterone receptor to its cognate progesterone responsive element (PRE) in cell-free experiments. We prepared unfractionated nuclear extracts from human breast cancer (