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Publikováno v:
Molecular Endocrinology. 12:954-961
As pituitary leukemia-inhibitory factor (LIF) mediates neuroimmune signals to the hypothalamo-pituitary-adrenal axis, we tested the role of intracellular SOCS-3 in corticotroph function. SOCS-3, a cytokine-inducible protein of the suppressor of cytok
Publikováno v:
Molecular Endocrinology. 11:2038-2047
In this report we show that extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2) respond differently to signals that elicit proliferation and/or differentiation of myoblasts using the C2C12 cell line and nondifferentiating mutant NFB4 cells
Publikováno v:
Molecular Endocrinology. 11:1094-1102
Homologous desensitization and internalization of the GLP-1 receptor correlate with phosphorylation of the receptor in a 33-amino acid segment of the cytoplasmic tail. Here, we identify the sites of phosphorylation as being three serine doublets loca
Publikováno v:
Molecular Endocrinology. 9:691-705
A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 diff
Publikováno v:
Molecular Endocrinology. 8:545-557
Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate insulin receptor substrate 1 (IRS-1), which in turn associates with and activates the enzyme phosphatidylinositol 3-kinase (PI
Publikováno v:
Molecular Endocrinology. 8:51-58
Chinese hamster ovary (CHO) cells were transfected with a cDNA encoding protein kinase C alpha (PKC) and a cell line (CHO-PKC alpha) expressing approximately 7-fold greater amounts of PKC as the parental cells were isolated. Activation of PKC by 12-O
Publikováno v:
Molecular Endocrinology. 5:1003-1012
A protein kinase capable of phosphorylating basic fibroblast growth factor (FGF) can be localized on the outer cell surface of human hepatoma cells (SK-Hep cells). The addition of [gamma-32P]ATP, but not H3(32)PO4, results in a rapid (less than 10 mi
Autor:
Donald A. McClain
Publikováno v:
Molecular Endocrinology. 5:734-739
The human insulin receptor (hIR) is expressed in two variant forms that are generated by tissue-specific alternative splicing of the 11th exon of the IR gene. This leads to receptors that differ in their affinities for insulin based on the absence (h
Autor:
Christopher S. Fry, Micah J. Drummond, Kyle L. Timmerman, Shaheen Dhanani, Blake B. Rasmussen, Erin L. Glynn, Melinda Sheffield-Moore, Hans C. Dreyer, Elena Volpi, Jessica Lee
Publikováno v:
Molecular Endocrinology. 24:1306-1306
Objective: Our objective was to determine whether endothelial-dependent vasodilation is an essential mechanism by which insulin stimulates human skeletal muscle protein synthesis and anabolism. Subjects: Subjects were healthy young adults (n = 14) ag
Autor:
Jerry L. Nadler, Runpei Wu, Swarup K. Chakrabarti, David A. Taylor-Fishwick, Kaiwen Ma, Craig S. Nunemaker
Publikováno v:
Molecular Endocrinology. 24:468-468
Context: Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs) produce active lipids that promote inflammatory damage by catalyzing the oxidation of linoleic and arachidonic acid, and LO