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Publikováno v:
Molecular Endocrinology. 12:568-579
Steroidal (ICI 182, 780) and nonsteroidal hydroxytamoxifen (OH-Tam) antiestrogens inhibit growth factor-mitogenic activity in MCF 7 estrogen receptor-positive human breast cancer cells. Cell inhibition is correlated with an increase in membrane prote
Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen
Publikováno v:
Molecular Endocrinology. 7:924-936
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work, the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breas
Publikováno v:
Molecular Endocrinology. 5:1740-1747
We studied the effects of interleukin-1 alpha (IL-1) and tumor necrosis factor-alpha (TNF), alone and in combination, on MCF-7 breast cancer cells to determine whether these cytokines alter cell growth, TNF gene expression, and TNF secretion. We foun
Autor:
Danielle Naville, Judith R. Head, J. Ian Mason, Diane S. Keeney, Graham Jenkin, Barbara A. Murry
Publikováno v:
Molecular Endocrinology. 5:1090-1100
In the steroidogenic pathways present in the gonads and adrenal cortex, 3 beta-hydroxysteroid dehydrogenase isomerase (3 beta HSD) is a key enzyme which controls the formation of delta 4-3-ketosteroids from delta 5-3 beta-hydroxysteroids. Herein, we
Publikováno v:
Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pitu
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Autor:
Gerald A. LeBlanc, Joseph J. Morrissey, David J. Waxman, Notani Gur, Scott S. Sundseth, Prabha A. Ram, John A. Alberta
Publikováno v:
Molecular Endocrinology. 4:447-454
Oligonucleotide probes that distinguish between two closely related mRNAs encoding steroid 6 beta-hydroxylases of rat P-450 gene family CYP3A were used to individually assess their responsiveness to pituitary hormone regulation. Northern blot analysi
Autor:
Alexandra L. Brown, Yvonne W.-H. Yang, Matthew M. Rechler, Joyce A. Romanus, Craig C. Orlowski, Terry Taylor, Lucy Y.-H. Tseng
Publikováno v:
Molecular Endocrinology. 3:1559-1568
The biological effects of the insulin-like growth factors, IGF-I and IGF-II, on their receptors are modulated by IGF-binding proteins. Recently, we isolated a cDNA clone for one member of the family of IGF-binding proteins, BP-3A, a 30 kilodalton (kD
Publikováno v:
Molecular Endocrinology. 3:225-231
Human tumors were analyzed for the presence of mRNA coding for basic fibroblast growth factor (basic FGF). Basic FGF transcript levels were consistently elevated in schwannoma samples (five acoustic neuromas and two spinal schwannomas) ranging from 9
Publikováno v:
Molecular Endocrinology. 1:233-242
The GH dependence of somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) and insulin like growth factor II (IGF-II) mRNAs was investigated by Northern blot hybridizations of polyadenylated RNAs from liver, pancreas, and brain of normal rats, untr