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Publikováno v:
Molecular Endocrinology. 19:1501-1515
The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distributio
Autor:
Dimitris K. Grammatopoulos, Danijela Markovic, Edward W. Hillhouse, Michael A. Levine, Thalia Teli
Publikováno v:
Molecular Endocrinology. 19:474-490
Attenuation of CRH receptor type 1 (CRH-R1) signaling activity might involve desensitization and uncoupling of CRH-R1 from intracellular effectors. We investigated the desensitization of native CRH-R in human myometrial cells from pregnant women and
Publikováno v:
Molecular Endocrinology. 15:1768-1780
PTP1B is a protein tyrosine phosphatase that negatively regulates insulin sensitivity by dephosphorylating the insulin receptor. Akt is a ser/thr kinase effector of insulin signaling that phosphorylates substrates at the consensus motif RXRXXS/T. Int
Autor:
Michael J. Quon, L. M. Karnitz, Robert V. Farese, Mary L. Standaert, Gautam Bandyopadhyay, Li-Na Cong, Mini P. Sajan
Publikováno v:
Molecular Endocrinology. 13:1766-1772
Previous studies have suggested that 1) atypical protein kinase C (PKC) isoforms are required for insulin stimulation of glucose transport, and 2) 3-phosphoinositide-dependent protein kinase-1 (PDK-1) is required for activation of atypical PKCs. Pres
Autor:
Olli A. Jänne, Paul M. Yen, Mark Trifiro, Jeannie Whang, William W. Chin, Ying Liu, Jorma J. Palvimo, Leonard Pinsky
Publikováno v:
Molecular Endocrinology. 11:162-171
Androgen, glucocorticoid, and progesterone receptors (ARs, GRs, and PRs) often can regulate transcription via composite hormone response elements in target genes. We have used artificial and natural mutant ARs from patients with androgen resistance t
Publikováno v:
Molecular Endocrinology. 9:1233-1239
Targeted disruption of the mouse Ftz-F1 gene, which encodes the orphan nuclear receptors steroidogenic factor 1 (SF-1) and embryonal long terminal repeat-binding protein (ELP), established that this gene is essential for development of the primary st
Publikováno v:
Molecular Endocrinology. 8:782-793
The role of testosterone (T) and 17 beta-estradiol (E2) in the control of chinook salmon gonadotropin II beta subunit (sGTHII beta) gene was examined. Both E2 and T specifically stimulated GTHII beta gene expression in cultured juvenile rainbow trout
Publikováno v:
Molecular Endocrinology. 8:794-805
Insulin-like growth factor-binding protein-1 (IGFBP-1) modulates the action of IGFs on target cells. IGFBP-1 transcription is highly regulated by hormonal and metabolic factors. In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by de
Autor:
Jia Li Gu, Jonathan Whittaker, Pierre De Meyts, Bruce E. Kaplan, Graeme I. Bell, Ronald M. Shymko
Publikováno v:
Molecular Endocrinology. 4:409-416
Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin receptor (INSR) and in insulin dimer formation, suggesting that this domain might also int