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Autor:
Anne E. Wallis, R H Devlin
Publikováno v:
Molecular Endocrinology. 7:409-422
Insulin-like growth factor (IGF-I) is a single chain, 70-amino acid, peptide hormone, which is essential to the process of growth and differentiation in higher vertebrates. IGF-I exhibits a very high degree of conservation throughout vertebrate evolu
Autor:
Maria Slomczynska, Arun K. Roy, Chung S. Song, Tekmal R. Rao, W. F. Demyan, Song Her, Dong S. Kim, Bandana Chatterjee, Wolfgang Gallwitz
Publikováno v:
Molecular Endocrinology. 6:589-597
Mammalian estrogen sulfotransferase (EST; EC 2.8.2.4) sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3'-phosphate-5'-phosphosulfate. Sulfurylated steroids do not bind to the estrogen re
Publikováno v:
Molecular Endocrinology. 4:1438-1443
When a human fetal muscle cDNA library was screened with the human thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA. The sequence of the insert was 2498 basepairs, with an open reading frame of 1794 basepair
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Autor:
Masahiro Nishi, Donald F. Steiner
Publikováno v:
Molecular Endocrinology. 4:1192-1198
The degu, Octodon degus, is a South American hystricomorph rodent that is of interest because it develops spontaneous diabetes mellitus and has been found to have islet amyloidosis. To help clarify these problems we have cloned cDNAs encoding islet a
Autor:
Terry F. Davies, P. Graves
Publikováno v:
Molecular Endocrinology. 4:155-161
A 0.95-kilobase (kb) thyrocyte RNA, initially detected in our 1B-6 subclone of Fisher rat thyrocytes (FRTL-5) using an oligonucleotide probe complementary to the 5' end of rat thyroglobulin (Tg) mRNA, was also detected in cultured thyrocytes of the W