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Publikováno v:
Molecular Endocrinology. 9:691-705
A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 diff
Autor:
Kathleen H. Day, Richard O. Day
Publikováno v:
Molecular Endocrinology. 8:12-20
Transplantation of GH3 rat pituitary tumor cells that express both PRL and GH to female Wistar-Furth rats results in tumors that secrete only GH. We have used in vivo passage of GH3 cells as a model system to study specific repression of PRL. RNA blo
Autor:
Palle Serup, Birgitte K. Michelsen, Niels Blume, Thomas Dyrberg, L C Andersen, Hans Kofod, Jacob S. Petersen, Ole D. Madsen
Publikováno v:
Molecular Endocrinology. 6:299-307
Synthetic peptides representing unique sequences in rat proinsulin C-peptide I and II were used to generate highly specific antisera, which, when applied on sections of normal rat pancreas, confirm a homogeneous coexpression of the two C-peptides in
Autor:
Prabha A. Ram, David J. Waxman
Publikováno v:
Molecular Endocrinology. 5:13-20
Studies carried out in hypophysectomized adult rats have demonstrated that both thyroid hormone and GH can suppress hepatic expression of the steroid 6 beta-hydroxylase P450 2a (IIIA2). The present study further characterizes the influence of thyroid
Publikováno v:
Molecular Endocrinology. 4:1438-1443
When a human fetal muscle cDNA library was screened with the human thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA. The sequence of the insert was 2498 basepairs, with an open reading frame of 1794 basepair
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Autor:
Masahiro Nishi, Donald F. Steiner
Publikováno v:
Molecular Endocrinology. 4:1192-1198
The degu, Octodon degus, is a South American hystricomorph rodent that is of interest because it develops spontaneous diabetes mellitus and has been found to have islet amyloidosis. To help clarify these problems we have cloned cDNAs encoding islet a
Publikováno v:
Molecular Endocrinology. 2:1077-1086
To obtain information about the functional significance of the structural heterogeneity that has been described for rat insulin-like growth factor I (IGF-I) cDNAs, we hybridized polyadenylated RNAs from rat tissues at different developmental stages w