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Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Gary L. Firestone, Shyam N. Sundar
Publikováno v:
Molecular Endocrinology. 23:1940-1947
Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented th
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Autor:
Dimitris K. Grammatopoulos, Danijela Markovic, Edward W. Hillhouse, Michael A. Levine, Thalia Teli
Publikováno v:
Molecular Endocrinology. 19:474-490
Attenuation of CRH receptor type 1 (CRH-R1) signaling activity might involve desensitization and uncoupling of CRH-R1 from intracellular effectors. We investigated the desensitization of native CRH-R in human myometrial cells from pregnant women and
Autor:
David F. Smith
Publikováno v:
Molecular Endocrinology. 7:1418-1429
A cell-free system was used to examine heat shock protein 90 (hsp90)-progesterone receptor (PR) binding at near physiological conditions. Four major findings are presented: 1) hsp90 is required to maintain ligand binding by PR at elevated temperature
Publikováno v:
Molecular Endocrinology. 6:995-1002
Almost 30 yr of studies have yielded a model for steroid hormone action that, except for the localization of steroid-free receptors, is basically the same for all steroids. At least for glucocorticoid receptors, the rate-determining step in nuclear b
Autor:
Bert W. O'Malley, Orla M. Conneely
Publikováno v:
Molecular Endocrinology. 6:1359-1361
Over the past 6 yr, we have witnessed a surprising increase in the number of known members in the steroid/thyroid/vitamin superfamily of intracellular receptors in a wide variety of species. Although the exact number of these proteins is difficult to