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Publikováno v:
Molecular Endocrinology. 30:402-416
The arcuate nucleus of the hypothalamus represents a key center for the control of appetite and feeding through the regulation of 2 key neuronal populations, notably agouti-related peptide/neuropeptide Y and proopimelanocortin (POMC)/cocaine- and amp
Autor:
Darawan Pinthong, Supachoke Mangmool, Sarawuth Phosri, Motohiro Nishida, Tsukasa Shimauchi, Tananat Denkaew, Warisara Parichatikanond
Publikováno v:
Molecular Endocrinology. 30:118-132
Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pat
Autor:
Christian Sell
Publikováno v:
Molecular Endocrinology. 29:1107-1113
A remarkable plasticity in life span has been uncovered in recent years, offering hope that the basic mechanisms of aging and interventions that delay aging may be identified in the coming decades. Life span extension has been achieved by genetic man
Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Autor:
Georgia A. Martin, Robert B. Gilchrist, Xiao-Yan Liang, David G. Mottershead, Lesley J. Ritter, Jing-Jie Li, Satoshi Sugimura, Thomas D. Mueller, Melissa White
Publikováno v:
Molecular Endocrinology. 29:40-52
Growth differentiation factor 9 (GDF9) is an oocyte-derived growth factor that plays a critical role in ovarian folliculogenesis and oocyte developmental competence and belongs to the TGF-β family of proteins. Recombinant human GDF9 (hGDF9) is secre
Publikováno v:
Molecular Endocrinology. 29:108-120
Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency, subsequent to both reduced β-cell mass and insufficient insulin secretion, and both augmenting β-cell mass and β-cell function are therapeutic strategies for treating T2DM.
Publikováno v:
Molecular Endocrinology. 28:406-417
Pancreatic β-cell death plays a role in both type 1 and type 2 diabetes, but clinical treatments that specifically target β-cell survival have not yet been developed. We have recently developed live-cell imaging-based, high-throughput screening met
Autor:
Sandeep Pawar, Elina Starosvetsky, Indrani C. Bagchi, Milan K. Bagchi, Grant D. Orvis, Richard R. Behringer
Publikováno v:
Molecular Endocrinology. 27:1996-2012
Embryo implantation is regulated by a variety of endometrial factors, including cytokines, growth factors, and transcription factors. Earlier studies identified the leukemia inhibitory factor (LIF), a cytokine produced by uterine glands, as an essent
Publikováno v:
Molecular Endocrinology. 27:536-547
Plasma membrane cholesterol accumulation has been implicated in cellular insulin resistance. Given the role of the hexosamine biosynthesis pathway (HBP) as a sensor of nutrient excess, coupled to its involvement in the development of insulin resistan
Publikováno v:
Molecular Endocrinology. 27:162-171
The increased insulin secretory burden placed on pancreatic β-cells during obesity and insulin resistance can ultimately lead to β-cell dysfunction and death and the development of type 2 diabetes. Mitogen-inducible gene 6 (Mig6) is a cellular stre