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Publikováno v:
Molecular Endocrinology. 18:1670-1686
Previous studies have shown that the synthesis and stability of milk protein mRNAs are regulated by lactogenic hormones. We demonstrate here in cultured mouse mammary epithelial cells (CID 9) that insulin plus prolactin also synergistically increases
Autor:
Olivier Goupille, Andrew Ziemiecki, Wolfgang Doppler, Claudia Soratroi, Martin Tonko, Sibylle Tonko-Geymayer, Charles H. Streuli, Reinhard Kofler, Akihiko Yoshimura
Publikováno v:
Molecular Endocrinology. 16:1680-1695
The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal tr
Autor:
Indrani C. Bagchi, Padmaja Ganapathy, Xueping Xu, Dahu Chen, Milan K. Bagchi, Li-Ji Zhu, Quanxi Li
Publikováno v:
Molecular Endocrinology. 13:993-1004
The steroid hormone estrogen profoundly influences the early events in the uterus leading to embryo implantation. It is thought that estrogen triggers the expression of a unique set of genes in the preimplantation endometrium that in turn control imp
Publikováno v:
Molecular Endocrinology. 11:997-1007
The growth-promoting activity of GH, the principal hormonal determinant of body size, is mediated by insulin-like growth factor I (IGF-I). Most of the IGF-I in plasma circulates in a 150-kDa complex that contains IGF-binding protein-3 (IGFBP-3) and a
Autor:
Diane M. Robins, Stefanie A. Nelson
Publikováno v:
Molecular Endocrinology. 11:460-469
The mouse sex-limited protein (Slp) gene is expressed in liver and kidney of adult males and is testosterone-inducible in females, indicative of androgen dependence. Analysis of mRNA levels and chromatin configuration reveals that this androgen regul
Publikováno v:
Molecular Endocrinology. 10:622-630
Insulin-dependent diabetes mellitus is associated with decreased levels of circulating insulin-like growth factor binding protein-3 (IGFBP-3), which are restored toward normal by treatment with insulin and/or infusion of insulin-like growth factor-I
Publikováno v:
Molecular Endocrinology. 9:691-705
A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 diff
Publikováno v:
Molecular Endocrinology. 9:350-360
Spontaneous production of insulin-like growth factor-I (IGF-I) by inflammatory macrophages contributes to aberrant wound healing, but little is known about regulation of IGF-I synthesis in myeloid cells. The T cell-derived cytokine interferon-gamma (
Publikováno v:
Molecular Endocrinology. 8:794-805
Insulin-like growth factor-binding protein-1 (IGFBP-1) modulates the action of IGFs on target cells. IGFBP-1 transcription is highly regulated by hormonal and metabolic factors. In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by de
Autor:
Kathleen H. Day, Richard O. Day
Publikováno v:
Molecular Endocrinology. 8:12-20
Transplantation of GH3 rat pituitary tumor cells that express both PRL and GH to female Wistar-Furth rats results in tumors that secrete only GH. We have used in vivo passage of GH3 cells as a model system to study specific repression of PRL. RNA blo