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Publikováno v:
Molecular Endocrinology. 25:611-620
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epitheli
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Publikováno v:
Molecular Endocrinology. 20:844-856
We have identified Kruppel-like factor 7 (KLF7) as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of KLF7 in the pathogenesis of type 2 diabetes, we examined the functional roles of KLF7 in var
Autor:
Wolfgang Schmid, Christoph Kellendonk, Christian Opherk, Andreas Schulze, François Tronche, Günther Schütz, Dirk Kohlmüller
Publikováno v:
Molecular Endocrinology. 18:1346-1353
Hepatic glucose production by gluconeogenesis is the main source of glucose during fasting and contributes significantly to hyperglycemia in diabetes mellitus. Accordingly, glucose metabolism is tightly controlled by a variety of hormones including i
Autor:
Julie M. Hall, Kenneth S. Korach
Publikováno v:
Molecular Endocrinology. 17:792-803
Recent clinical studies estimate that 60-70% of human ovarian and breast cancers overexpress the estrogen receptor (ER). However, despite the established mitogenic effects of estrogen in these tumors, proliferative markers of hormone action are limit
Autor:
Nicos A. Nicola, Patrick Bertolino, Jason Corbin, Helen W. Davey, Douglas J. Hilton, Donald Metcalf, Sylvia L. Asa, Christopher J. Greenhalgh, Warren S. Alexander, Timothy E. Adams
Publikováno v:
Molecular Endocrinology. 16:1394-1406
Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the prod
Autor:
Maribel Rios, Joseph Kelly, Guoping Fan, Rudolf Jaenisch, Brian Bates, Ronald M. Lechan, Ralf Kuehn, Csaba Fekete
Publikováno v:
Molecular Endocrinology. 15:1748-1757
Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role of this neurotrophin in weight regulation, we have generated conditional mutants in which brain-derived neurotrophic facto
Publikováno v:
Molecular Endocrinology. 14:1472-1482
Insulin-like growth factor binding protein 2 (IGFBP-2) is one member of the family of IGF binding proteins believed to have both endocrine functions elicited by modulating serum IGF half-life and transport as well as autocrine/paracrine functions tha
Autor:
Darryl L. Russell, JoAnne S. Richards
Publikováno v:
Molecular Endocrinology. 13:2049-2064
PRL activates an important cytokine signaling cascade that is obligatory for maintaining luteal cell function in the rat ovary. To determine when specific components of this cascade are expressed and can be activated by PRL, we analyzed the expressio
Publikováno v:
Molecular Endocrinology. 12:954-961
As pituitary leukemia-inhibitory factor (LIF) mediates neuroimmune signals to the hypothalamo-pituitary-adrenal axis, we tested the role of intracellular SOCS-3 in corticotroph function. SOCS-3, a cytokine-inducible protein of the suppressor of cytok