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Publikováno v:
Molecular Endocrinology. 19:1501-1515
The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distributio
Autor:
Kelce Wr, Kathy Bobseine, Elizabeth Langley, Choi iok Wong, Elizabeth M. Wilson, Jon A. Kemppainen
Publikováno v:
Molecular Endocrinology. 13:440-454
Natural and pharmacological androgen receptor (AR) ligands were tested for their ability to induce the AR NH2-terminal and carboxyl-terminal (N/C) interaction in a two-hybrid protein assay to determine whether N/C complex formation distinguishes in v
Publikováno v:
Molecular Endocrinology. 9:1791-1803
PML (promyelocytic leukemia) is a protein involved in the t (15;17) translocation of promyelocytic leukemia and is mainly localized in nuclear bodies. Here we show that PML exerts a very powerful enhancing activity (up to 20-fold) on the transactivat
Publikováno v:
Molecular Endocrinology. 9:1233-1239
Targeted disruption of the mouse Ftz-F1 gene, which encodes the orphan nuclear receptors steroidogenic factor 1 (SF-1) and embryonal long terminal repeat-binding protein (ELP), established that this gene is essential for development of the primary st
Publikováno v:
Molecular Endocrinology. 6:2090-2102
The effect of glucocorticoids on the regulation of stably transfected human glucocorticoid receptors has been examined. Exposure of a Chinese hamster ovary-derived cell line containing stably transfected human glucocorticoid receptor genes and glucoc
Publikováno v:
Molecular Endocrinology. 3:1270-1278
Progesterone receptor-containing T47D human breast cancer cells are responsive to progestins but fail to respond to other steroid hormones, in particular dexamethasone, because they have no measurable levels of receptors for estrogens, androgens, or
Publikováno v:
Molecular Endocrinology. 1:569-576
Expression of the endogenous human GH (hGH) gene in response to glucocorticoids, thyroid hormone, and insulin was studied in cultures of dispersed GH-secreting human pituitary adenomas. Results were compared to those obtained when the hGH gene was tr