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Publikováno v:
Molecular Endocrinology. 30:402-416
The arcuate nucleus of the hypothalamus represents a key center for the control of appetite and feeding through the regulation of 2 key neuronal populations, notably agouti-related peptide/neuropeptide Y and proopimelanocortin (POMC)/cocaine- and amp
Autor:
Darawan Pinthong, Supachoke Mangmool, Sarawuth Phosri, Motohiro Nishida, Tsukasa Shimauchi, Tananat Denkaew, Warisara Parichatikanond
Publikováno v:
Molecular Endocrinology. 30:118-132
Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pat
Autor:
Hong Yang, Xuemian Lu, Fangfang Zhang, Peng Cheng, Yi Tan, Xiaokun Li, Lu Cai, Xiufei Lin, Chi Zhang, Luqing He, Lechu Yu
Publikováno v:
Molecular Endocrinology. 29:1400-1413
Fibroblast growth factor (FGF)19 and FGF21 are hormones that regulate metabolic processes particularly during feeding or starvation, thus ultimately influencing energy production. FGF19 is secreted by the intestines during feeding and negatively regu
Autor:
Chunxue Wang, Martin Egli, Michael R. Waterman, F. Peter Guengerich, Pradeep S. Pallan, Li Lei
Publikováno v:
Molecular Endocrinology. 29:1375-1384
Cytochrome P450 21A2 is a key player in steroid 21-hydroxylation and converts progesterone to 11-deoxycorticosterone and 17α-hydroxy progesterone to 11-deoxycortisol. More than 100 mutations in P450 21A2 have been established in patients thus far; t
Autor:
Raghavendra G. Mirmira, Medha Priyadarshini, Charles R. Mackay, Thierry Alquier, Annette Gilchrist, Helena Mancebo, Barton Wicksteed, Vincent Poitout, Miles Fuller, Stephanie R. Villa, Brian T. Layden
Publikováno v:
Molecular Endocrinology. 29:1055-1066
G protein-coupled receptors have been well described to contribute to the regulation of glucose-stimulated insulin secretion (GSIS). The short-chain fatty acid-sensing G protein-coupled receptor, free fatty acid receptor 2 (FFAR2), is expressed in pa
Autor:
Haochen Li, Thurl E. Harris, Chien Li, Hongxia Chao, Zhen Yan, Vitor A. Lira, Rebecca C. Grande
Publikováno v:
Molecular Endocrinology. 29:831-841
Type 2 corticotropin-releasing factor receptor (CRFR2) is expressed in skeletal muscle and stimulation of the receptor has been shown to inhibit the effect of insulin on glucose uptake in muscle cells. Currently, little is known about the mechanisms
Autor:
Esther Bolanis, Theodore R. Holman, Raghavendra G. Mirmira, Jerry L. Nadler, Sarah A. Tersey, David J. Maloney
Publikováno v:
Molecular Endocrinology. 29:791-800
The insulin producing islet β-cells have increasingly gained attention for their role in the pathogeneses of virtually all forms of diabetes. Dysfunction, de-differentiation, and/or death of β-cells are pivotal features in the transition from normo
Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Publikováno v:
Molecular Endocrinology. 29:108-120
Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency, subsequent to both reduced β-cell mass and insufficient insulin secretion, and both augmenting β-cell mass and β-cell function are therapeutic strategies for treating T2DM.
Autor:
Sabire Özcan
Publikováno v:
Molecular Endocrinology. 28:1922-1933
MicroRNAs are small noncoding ribonucleotides that regulate mRNA translation or degradation and have major roles in cellular function. MicroRNA (miRNA) levels are deregulated or altered in many diseases. There is overwhelming evidence that miRNAs als