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Autor:
Esther Bolanis, Theodore R. Holman, Raghavendra G. Mirmira, Jerry L. Nadler, Sarah A. Tersey, David J. Maloney
Publikováno v:
Molecular Endocrinology. 29:791-800
The insulin producing islet β-cells have increasingly gained attention for their role in the pathogeneses of virtually all forms of diabetes. Dysfunction, de-differentiation, and/or death of β-cells are pivotal features in the transition from normo
Publikováno v:
Molecular Endocrinology. 24:1423-1433
Most people with type 2 diabetes (T2D) have reduced beta-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high gluco
Autor:
Alan J. Fox, Klaus H. Kaestner, Rana K. Gupta, Sebastian Rieck, Olga Smirnova, Peter White, Jonathan Schug, Philipp E. Scherer, Nan Gao, Mark P. Keller, Alan D. Attie, Zhao V. Wang
Publikováno v:
Molecular Endocrinology. 23:1702-1712
The inability of the ss-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, ss-cell replication is one of the mechanisms thought to cause the expansion of ss-cell mass. Efforts to treat diabete
Publikováno v:
Molecular Endocrinology. 21:2785-2794
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed to investigate the function of miRNAs in type 2 diabetes mellit
Autor:
Harald Staiger, Johanna Kuusisto, Fritz Schick, Claus D. Claussen, Karsten Müssig, Jürgen Machann, Alena Stančáková, Andreas Fritsche, Claus Thamer, Norbert Stefan, Markku Laakso, Hans-Ulrich Häring, Fausto Machicao
Publikováno v:
Molecular Endocrinology. 23:278-279
The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver.The objective of the study was to investigate whether common genetic variation within the F