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Autor:
Darawan Pinthong, Supachoke Mangmool, Sarawuth Phosri, Motohiro Nishida, Tsukasa Shimauchi, Tananat Denkaew, Warisara Parichatikanond
Publikováno v:
Molecular Endocrinology. 30:118-132
Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pat
Publikováno v:
Molecular Endocrinology. 24:1423-1433
Most people with type 2 diabetes (T2D) have reduced beta-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high gluco
Autor:
Erik C. Rocheford, Tara L. Mullarkey, Nico Mitro, Xue Li, Enrique Saez, Patrick Kennedy, S. Renee Commerford, Leo Vargas, Puiying A. Mak, Suzanne E. Dorfman
Publikováno v:
Molecular Endocrinology. 21:3002-3012
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with synthetic LXR ligands enhances glucose tolerance, inducing changes in gene expression expected
Publikováno v:
Molecular Endocrinology. 21:2785-2794
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed to investigate the function of miRNAs in type 2 diabetes mellit
Autor:
Ming Ding, Tomomi Miyamoto, Paul S. Kim, Ji-Ming Cheng, Takashi Agui, Sen-ichi Furudate, Cha-Gyun Jung, Bailing Li, Shekar Menon
Publikováno v:
Molecular Endocrinology. 14:1944-1953
A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent
Publikováno v:
Molecular Endocrinology. 11:833-837
Type 1 diabetes mellitus is caused by a lack of insulin that results from the autoimmune destruction of the pancreatic beta-cells. Severe diabetes, if not controlled by periodic insulin injections, can lead to ketoacidosis and death. We have previous
Autor:
Lucia Monaco, Paolo Sassone-Corsi, Martti Parvinen, Enzo Lalli, Katherine Tamai, Tero-Pekka Alastalo
Publikováno v:
Molecular Endocrinology. 10:1561-1569
Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. DAX-1 has been proposed to play a role in steroidogenesis because it is highly expressed in adrenocortical and testicular Leydig cells
Publikováno v:
Molecular Endocrinology. 10:622-630
Insulin-dependent diabetes mellitus is associated with decreased levels of circulating insulin-like growth factor binding protein-3 (IGFBP-3), which are restored toward normal by treatment with insulin and/or infusion of insulin-like growth factor-I
Publikováno v:
Molecular Endocrinology. 6:2219-2228
Insulin-like growth factor-binding protein-1 (IGFBP-1) can inhibit or potentiate IGF action. The biological activity of IGFBP-1 is determined by many factors, including its abundance in tissues and plasma, posttranslational modifications, and localiz
Autor:
Palle Serup, Birgitte K. Michelsen, Niels Blume, Thomas Dyrberg, L C Andersen, Hans Kofod, Jacob S. Petersen, Ole D. Madsen
Publikováno v:
Molecular Endocrinology. 6:299-307
Synthetic peptides representing unique sequences in rat proinsulin C-peptide I and II were used to generate highly specific antisera, which, when applied on sections of normal rat pancreas, confirm a homogeneous coexpression of the two C-peptides in