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Publikováno v:
Molecular Endocrinology. 10:713-722
Bone loss observed in postmenopausal women is clearly associated with a decrease in estrogen levels. Interleukin 6 (IL-6), a multifunctional cytokine involved in osteoclast differentiation, is secreted by osteoblasts and appears to be a key molecule
Autor:
Jeffrey M. Rosen, S Coleman-Krnacik
Publikováno v:
Molecular Endocrinology. 8:218-229
Mammary gland development is dependent upon local regulatory factors as well as systemic hormones to mediate gland morphogenesis and associated mesenchymal-epithelial interactions. FGF-3 (int-2) has been implicated as an oncogenic growth factor produ
Publikováno v:
Molecular Endocrinology. 6:2123-2128
The growth of isolated epithelial and stromal cells from both androgen-dependent normal rat prostate and an androgen-responsive model rat prostate tumor is androgen-independent. When added to co-cultures of epithelial and stromal cells separated by a
Publikováno v:
Molecular Endocrinology. 4:1144-1152
The Y1 mouse adrenocortical tumor cell line retains the ability to synthesize and secrete steroids, but does not express steroid 21-hydroxylase (C21) and, therefore, does not produce 21-hydroxylated steroids. In this investigation the mechanisms unde
Autor:
Omar Pedro Pignataro, Mario Ascoli
Publikováno v:
Molecular Endocrinology. 4:758-765
In a recent publication we showed that addition of mouse epidermal growth factor (mEGF) to MA-10 Leydig tumor cells rapidly leads to an increase in the incorporation of [3H]inositol-derived radioactivity into an unusual lipid that was identified as p
Autor:
Lawrence Tamarkin, Giulio F. Paciotti
Publikováno v:
Molecular Endocrinology. 2:459-464
Direct in vitro effects of IL-1 on hormone-dependent (MCF-7 and ZR-75-B) and independent (HS-578-T and MDA-231) human breast cancer cell proliferation were investigated in short-term and long-term cell cultures. For short-term (48 h) studies [3H]thym
Publikováno v:
Molecular Endocrinology. 1:569-576
Expression of the endogenous human GH (hGH) gene in response to glucocorticoids, thyroid hormone, and insulin was studied in cultures of dispersed GH-secreting human pituitary adenomas. Results were compared to those obtained when the hGH gene was tr
Publikováno v:
Molecular Endocrinology. 3:225-231
Human tumors were analyzed for the presence of mRNA coding for basic fibroblast growth factor (basic FGF). Basic FGF transcript levels were consistently elevated in schwannoma samples (five acoustic neuromas and two spinal schwannomas) ranging from 9