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Autor:
Ai Li Yeo, Peter Nowotny, Maria Nilsson, Edison T. Liu, Thomas M. Stulnig, Chin-Yo Lin, Knut R. Steffensen
Publikováno v:
Molecular Endocrinology. 21:126-137
The nuclear hormone receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Adr
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Autor:
Donald B. DeFranco
Publikováno v:
Molecular Endocrinology. 16:1449-1455
Steroid hormone receptors exert much of their effects on cellular physiology through regulating the rate of transcription from unique target genes. Much has been learned about the actions of steroid hormone receptors at regulated promoters through mo
Publikováno v:
Molecular Endocrinology. 15:1993-2009
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expre
Autor:
John P. Lydon, Russell C. Hovey, Barbara K. Vonderhaar, Tiffany N. Seagroves, Jeffrey M. Rosen
Publikováno v:
Molecular Endocrinology. 14:359-368
Deletion of the transcription factor CCAAT/enhancer binding protein (C/EBP)β results in a severe inhibition of lobuloalveolar development in the mouse mammary gland. Because progesterone receptor (PR) is requisite for alveolar development, the expre
Autor:
Indrani C. Bagchi, Padmaja Ganapathy, Xueping Xu, Dahu Chen, Milan K. Bagchi, Li-Ji Zhu, Quanxi Li
Publikováno v:
Molecular Endocrinology. 13:993-1004
The steroid hormone estrogen profoundly influences the early events in the uterus leading to embryo implantation. It is thought that estrogen triggers the expression of a unique set of genes in the preimplantation endometrium that in turn control imp
Publikováno v:
Molecular Endocrinology. 11:801-811
A combination of a knockout mouse model, tissue transplantation, and gene expression analysis has been used to investigate the role of steroid hormones in mammary gland development. Mouse mammary gland development was examined in progesterone recepto
Autor:
Lucia Monaco, Paolo Sassone-Corsi, Martti Parvinen, Enzo Lalli, Katherine Tamai, Tero-Pekka Alastalo
Publikováno v:
Molecular Endocrinology. 10:1561-1569
Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. DAX-1 has been proposed to play a role in steroidogenesis because it is highly expressed in adrenocortical and testicular Leydig cells
Publikováno v:
Molecular Endocrinology. 8:782-793
The role of testosterone (T) and 17 beta-estradiol (E2) in the control of chinook salmon gonadotropin II beta subunit (sGTHII beta) gene was examined. Both E2 and T specifically stimulated GTHII beta gene expression in cultured juvenile rainbow trout
Autor:
Ganesan Srinivasan
Publikováno v:
Molecular Endocrinology. 6:857-860
The cloning of cDNAs for the various members of the steroid/thyroid receptor family has sparked a flurry of research that has revealed many aspects of receptor structure and function (1, 2). Much of the information has come from mutational analysis o