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Publikováno v:
Molecular Endocrinology. 29:1787-1791
Recently, several LH/human chorionic gonadotropin (hCG) receptor-independent activities for hCG have been described, including activation of the TGF-β receptor (TGFβR) by hyperglycosylated hCG and stimulation of trophoblast invasion. Because the hC
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Autor:
Jacques Emile Dumont, Bernard Corvilain, Ling Jin, Catherine Ledent, Paul Van Hummelen, Hortensia Mircescu, Jean-Christophe Goffard
Publikováno v:
Molecular Endocrinology. 18:194-213
Mutations of the TSH receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and nonautoimmune hyperthyroidism, when occurring in a germinal cell. An animal mod
Publikováno v:
Molecular Endocrinology. 17:472-486
The insulin receptor substrate 1 (IRS-1) can translocate to the nuclei and nucleoli of several types of cells. Nuclear translocation can be induced by an activated insulin-like growth factor 1 receptor (IGF-IR), and by certain oncogenes, such as the
Autor:
Donald B. DeFranco
Publikováno v:
Molecular Endocrinology. 16:1449-1455
Steroid hormone receptors exert much of their effects on cellular physiology through regulating the rate of transcription from unique target genes. Much has been learned about the actions of steroid hormone receptors at regulated promoters through mo
Autor:
John P. Lydon, Russell C. Hovey, Barbara K. Vonderhaar, Tiffany N. Seagroves, Jeffrey M. Rosen
Publikováno v:
Molecular Endocrinology. 14:359-368
Deletion of the transcription factor CCAAT/enhancer binding protein (C/EBP)β results in a severe inhibition of lobuloalveolar development in the mouse mammary gland. Because progesterone receptor (PR) is requisite for alveolar development, the expre
Publikováno v:
Molecular Endocrinology. 10:826-836
Interferon-gamma (IFN gamma) is known to suppress the expression of thyroid-specific genes, such as thyroglobulin, thyroid peroxidase, and the TSH receptor (TSHR). In the present study, we show that this reflects, in part, a transcriptional action me
Autor:
Lynn R. Carnaghi, Stephen J. Giddings
Publikováno v:
Molecular Endocrinology. 6:1665-1672
Insulin gene expression has been demonstrated in nonpancreatic tissues early in development, suggesting that this hormone might have actions significant for the differentiating embryo. Because such actions imply ligand-receptor binding, we quantified
Autor:
Ganesan Srinivasan
Publikováno v:
Molecular Endocrinology. 6:857-860
The cloning of cDNAs for the various members of the steroid/thyroid receptor family has sparked a flurry of research that has revealed many aspects of receptor structure and function (1, 2). Much of the information has come from mutational analysis o
Autor:
Bert W. O'Malley
Publikováno v:
Molecular Endocrinology. 4:363-369
The overall molecular pathway for the action of steroid hormones has been known for the past 15 yr (1–9). Within the past 5 yr, the cDNAs for all major steroid hormones have been cloned and sequenced (10, 11). As might have been expected, they were