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Publikováno v:
Molecular Endocrinology. 30:402-416
The arcuate nucleus of the hypothalamus represents a key center for the control of appetite and feeding through the regulation of 2 key neuronal populations, notably agouti-related peptide/neuropeptide Y and proopimelanocortin (POMC)/cocaine- and amp
Autor:
Haochen Li, Thurl E. Harris, Chien Li, Hongxia Chao, Zhen Yan, Vitor A. Lira, Rebecca C. Grande
Publikováno v:
Molecular Endocrinology. 29:831-841
Type 2 corticotropin-releasing factor receptor (CRFR2) is expressed in skeletal muscle and stimulation of the receptor has been shown to inhibit the effect of insulin on glucose uptake in muscle cells. Currently, little is known about the mechanisms
Autor:
Adolfo Garcia-Ocaña, Ann Marie Segal, Juan Carlos Alvarez-Perez, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 29 (2015): 542–547. doi:10.1210/me.2014-1273
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
Human islet ?-cells exploit an autocrine dopamine (DA)-mediated inhibitory circuit to regulate insulin secretion. ?-Cells also express the DA active transporter and the large neutral amino acid transporter heterodimer enabling them to import circulat
Autor:
Georgia A. Martin, Robert B. Gilchrist, Xiao-Yan Liang, David G. Mottershead, Lesley J. Ritter, Jing-Jie Li, Satoshi Sugimura, Thomas D. Mueller, Melissa White
Publikováno v:
Molecular Endocrinology. 29:40-52
Growth differentiation factor 9 (GDF9) is an oocyte-derived growth factor that plays a critical role in ovarian folliculogenesis and oocyte developmental competence and belongs to the TGF-β family of proteins. Recombinant human GDF9 (hGDF9) is secre
Publikováno v:
Molecular Endocrinology. 28:406-417
Pancreatic β-cell death plays a role in both type 1 and type 2 diabetes, but clinical treatments that specifically target β-cell survival have not yet been developed. We have recently developed live-cell imaging-based, high-throughput screening met
Autor:
Sandeep Pawar, Elina Starosvetsky, Indrani C. Bagchi, Milan K. Bagchi, Grant D. Orvis, Richard R. Behringer
Publikováno v:
Molecular Endocrinology. 27:1996-2012
Embryo implantation is regulated by a variety of endometrial factors, including cytokines, growth factors, and transcription factors. Earlier studies identified the leukemia inhibitory factor (LIF), a cytokine produced by uterine glands, as an essent
Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Autor:
Helmut Grasberger, Olga Barca Mayo, Mia C. Weiss, Samuel Refetoff, Xavier De Deken, Xiao Hui Liao, Houssam Raad
Publikováno v:
Molecular Endocrinology. 26:481-492
Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen peroxide (H(2)O(2)) release of epithelial cells. Specific maturation factors (DUOXA1 and DUOXA2
Autor:
Shinichi Yamashita, Chawnshang Chang, Chih-Rong Shyr, Shuyuan Yeh, Kuo Pao Lai, Spencer Vitkus
Publikováno v:
Molecular Endocrinology. 26:52-66
Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior pros
Publikováno v:
Molecular Endocrinology. 25:2041-2053
Overexpression of steroid receptor coactivator (SRC)-1 and SRC-3 is associated with cancer initiation, metastasis, advanced disease, and resistance to chemotherapy. In most of these cases, SRC-1 and SRC-3 have been shown to promote tumor cell growth