Zobrazeno 61 - 70
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Autor:
Christopher S. Fry, Micah J. Drummond, Kyle L. Timmerman, Shaheen Dhanani, Blake B. Rasmussen, Erin L. Glynn, Melinda Sheffield-Moore, Hans C. Dreyer, Elena Volpi, Jessica Lee
Publikováno v:
Molecular Endocrinology. 24:1306-1306
Objective: Our objective was to determine whether endothelial-dependent vasodilation is an essential mechanism by which insulin stimulates human skeletal muscle protein synthesis and anabolism. Subjects: Subjects were healthy young adults (n = 14) ag
Autor:
Jerry L. Nadler, Runpei Wu, Swarup K. Chakrabarti, David A. Taylor-Fishwick, Kaiwen Ma, Craig S. Nunemaker
Publikováno v:
Molecular Endocrinology. 24:468-468
Context: Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs) produce active lipids that promote inflammatory damage by catalyzing the oxidation of linoleic and arachidonic acid, and LO
Autor:
Inkyu Lee, Min Hu, Li Wang, Jiansheng Huang, Pradip K. Saha, Yong-Deuk Kim, Keun-Gyu Park, David D. Moore, Rohit N. Kulkarni, Arun S. Rajan, Lawrence Chan
Publikováno v:
Molecular Endocrinology. 22:2203-2203
The orphan receptor small heterodimer partner (SHP; NROB2) is a transcriptional repressor that inhibits nuclear receptor signaling in diverse metabolic pathways. Here, we report that SHP(-/-) mice exhibited hypoinsulinemia with age, which was associa
Autor:
Lisa H. Fish, W B Kinlaw, Harold L. Schwartz, Ana Perez-Castillo, Cary N. Mariash, Jack H. Oppenheimer
Publikováno v:
Molecular Endocrinology. 1:609-613
The mRNA of the rat hepatic S14 gene accumulates rapidly after administration of T3 and carbohydrate, making it an excellent model for studies of the effects of dietary and hormonal stimuli at the hepatocellular level. We undertook studies to assess
Publikováno v:
Molecular Endocrinology. 2:528-535
Alternative splicing of insulin-like growth factor I (IGF-I)/somatomedin C mRNAs generates two IGF-I mRNAs coding for IGF-I peptides with different sequences in the E domain of the IGF-I prohormone. These two mRNAs encode alternative E peptides due t
Autor:
Jean-Pierre Gagner, Jacques Drouin
Publikováno v:
Molecular Endocrinology. 1:677-682
The release of pituitary hormones derived from POMC is under multihormonal and tissue-specific control in the anterior and intermediate lobes of the pituitary where the same single-copy POMC gene is expressed. In order to assess the tissue-specificit
Publikováno v:
Molecular Endocrinology. 3:1132-1141
In two cellular models of insulin resistance we measured glucose transport activity, total glucose transporter number using the cytochalasin B binding assay, and expression of a transporter mRNA species specifically hybridizing with cDNA cloned from
Publikováno v:
Molecular Endocrinology. 3:887-894
The inhibitory effects of recombinant porcine interferon-gamma (IFN gamma) on human CG (hCG)-stimulated testosterone production, and on mRNA concentrations of cholesterol side-chain cleavage (P450scc) and 17 alpha-hydroxylase/C17-20lyase (P450c 17) w
Publikováno v:
Molecular Endocrinology. 2:1256-1264
The mechanism of ligand-induced (homologous) down-regulation of the glucocorticoid receptor (GR) has been studied. Dexamethasone caused a down-regulation of the levels of GR mRNA and protein both in hepatoma tissue culture cells and rat liver in vivo
Autor:
Alexandra L. Brown, Yvonne W.-H. Yang, Matthew M. Rechler, Joyce A. Romanus, Craig C. Orlowski, Terry Taylor, Lucy Y.-H. Tseng
Publikováno v:
Molecular Endocrinology. 3:1559-1568
The biological effects of the insulin-like growth factors, IGF-I and IGF-II, on their receptors are modulated by IGF-binding proteins. Recently, we isolated a cDNA clone for one member of the family of IGF-binding proteins, BP-3A, a 30 kilodalton (kD