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Autor:
Antonio Brunetti, Monica Fedele, Daniela Foti, Katiuscia Possidente, Eusebio Chiefari, Stefania Iiritano, Maria T. Nevolo, Valeria Ventura, Alfredo Fusco, Adelaide Greco, Aurora Nocera, Giuseppe Brunetti, Manfredi Greco, Biagio Arcidiacono
Publikováno v:
Molecular Endocrinology. 26:1578-1589
We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, causing a type 2-
Autor:
Helmut Grasberger, Olga Barca Mayo, Mia C. Weiss, Samuel Refetoff, Xavier De Deken, Xiao Hui Liao, Houssam Raad
Publikováno v:
Molecular Endocrinology. 26:481-492
Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen peroxide (H(2)O(2)) release of epithelial cells. Specific maturation factors (DUOXA1 and DUOXA2
Autor:
Shinichi Yamashita, Chawnshang Chang, Chih-Rong Shyr, Shuyuan Yeh, Kuo Pao Lai, Spencer Vitkus
Publikováno v:
Molecular Endocrinology. 26:52-66
Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior pros
Publikováno v:
Molecular Endocrinology. 25:611-620
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epitheli
Publikováno v:
Molecular Endocrinology. 24:1423-1433
Most people with type 2 diabetes (T2D) have reduced beta-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high gluco
Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy
Autor:
E. Dale Abel, Adam R. Wende, Sandra Sena, Benjamin Wayment, Derek LeRoith, Heather A. Theobald, Crystal Sloan, Sheldon E. Litwin, Martin Holzenberger, Jaetaek Kim, Jamie Soto
Publikováno v:
Molecular Endocrinology. 22:2531-2543
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1R
Autor:
Ai Li Yeo, Peter Nowotny, Maria Nilsson, Edison T. Liu, Thomas M. Stulnig, Chin-Yo Lin, Knut R. Steffensen
Publikováno v:
Molecular Endocrinology. 21:126-137
The nuclear hormone receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Adr
Autor:
Jennifer Rieusset, Silvia I. Anghel, Walter Wahli, Pierre Chambon, Daniel Metzger, Pascal Escher, Béatrice Desvergne, Liliane Michalik, Nguan Soon Tan, Josiane Seydoux
Publikováno v:
Molecular Endocrinology. 18:2363-2377
The peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in fat tissue development and physiology. Mutations in the gene encoding this receptor have been associated to disorders in lipid metabolism. A thorough investigation of mi
Autor:
Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski
Publikováno v:
Molecular Endocrinology. 17:93-106
Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin se
Autor:
Meng Chun Hu, Nai Chi Hsu, Hsueh-Ping Chu, Bon Chu Chung, Chi-Kuang Leo Wang, Noomen Ben El Hadj, Chin I. Pai
Publikováno v:
Molecular Endocrinology. 16:1943-1950
Steroid deficiencies are diseases affecting salt levels, sugar levels, and sexual differentiation. To study steroid deficiency in more detail, we used a gene-targeting technique to insert a neo gene into the first exon to disrupt Cyp11a1, the first g