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Autor:
Christian Sell
Publikováno v:
Molecular Endocrinology. 29:1107-1113
A remarkable plasticity in life span has been uncovered in recent years, offering hope that the basic mechanisms of aging and interventions that delay aging may be identified in the coming decades. Life span extension has been achieved by genetic man
Autor:
Antonio Brunetti, Monica Fedele, Daniela Foti, Katiuscia Possidente, Eusebio Chiefari, Stefania Iiritano, Maria T. Nevolo, Valeria Ventura, Alfredo Fusco, Adelaide Greco, Aurora Nocera, Giuseppe Brunetti, Manfredi Greco, Biagio Arcidiacono
Publikováno v:
Molecular Endocrinology. 26:1578-1589
We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, causing a type 2-
Autor:
Shinichi Yamashita, Chawnshang Chang, Chih-Rong Shyr, Shuyuan Yeh, Kuo Pao Lai, Spencer Vitkus
Publikováno v:
Molecular Endocrinology. 26:52-66
Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior pros
Autor:
Norihiko Mori, Yoshiyuki Soeda, Naoki Toyooka, Xu Wang, Shuji Hosoh, Syota Kagawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Teruko Uwano, Hayato Muranaka, Yoshinori Ichihara, Yusaku Takamura, Tsutomu Wada, Hisao Nishijo
Publikováno v:
Molecular Endocrinology. 24:1965-1977
Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that
Autor:
Sophie Giorgetti-Peraldi, Marie-Noëlle Monthouël-Kartmann, Joseph Murdaca, Emmanuel Van Obberghen, Caroline Treins
Publikováno v:
Molecular Endocrinology. 19:1304-1317
Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-inde
Autor:
Nicos A. Nicola, Patrick Bertolino, Jason Corbin, Helen W. Davey, Douglas J. Hilton, Donald Metcalf, Sylvia L. Asa, Christopher J. Greenhalgh, Warren S. Alexander, Timothy E. Adams
Publikováno v:
Molecular Endocrinology. 16:1394-1406
Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the prod
Autor:
Ester Coronado-Heinsohn, Jennifer L. Gooch, Adrian V. Lee, Douglas Yee, C K Osborne, Susan G. Hilsenbeck, James G. Jackson
Publikováno v:
Molecular Endocrinology. 13:787-796
Cross-talk between insulin-like growth factor (IGF)- and estrogen receptor (ER)-signaling pathways results in synergistic growth. We show here that estrogen enhances IGF signaling by inducing expression of three key IGF-regulatory molecules, the type
Publikováno v:
Molecular Endocrinology. 12:1708-1720
Leukemia inhibitory factor (LIF) regulates the mature hypothalamic-pituitary-adrenal axis in vivo. In vitro, LIF determines corticotroph cell proliferation and induces POMC transcription. To explore LIF action on pituitary development, transgenic mic
Publikováno v:
Molecular Endocrinology. 12:825-834
Insulin-like growth factor I (IGF-I)/insulin induced cytosolic p42/p44 mitogen-activated protein kinase (MAPK) activation in a time-dependent manner in fetal brown adipocytes, reaching a maximum at 5 min. Concurrently, nuclear p42/p44 MAPKs were also
Publikováno v:
Molecular Endocrinology. 12:568-579
Steroidal (ICI 182, 780) and nonsteroidal hydroxytamoxifen (OH-Tam) antiestrogens inhibit growth factor-mitogenic activity in MCF 7 estrogen receptor-positive human breast cancer cells. Cell inhibition is correlated with an increase in membrane prote