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Autor:
Dongmei Wu, Alan J. Mears, Alexander Sorisky, Houssein Abdou Salem, Adèle Boudreau, Ella Atlas, Julianna J. Tomlinson, AnneMarie Gagnon, Robert J. G. Haché, Amanda Carrigan
Publikováno v:
Molecular Endocrinology. 24:104-113
Glucocorticoids are synthesized locally in adipose tissue and contribute to metabolic disease through the facilitation of adipose tissue expansion. Here we report that exposure of human primary preadipocytes to glucocorticoids increases their sensiti
Autor:
Jerrold M. Olefsky, Jennie L. Babendure, Juu Chin Lu, Christopher J. Hupfeld, Takeshi Imamura, Isao Usui, Hiroaki Satoh
Publikováno v:
Molecular Endocrinology. 19:2760-2768
G protein-coupled receptor kinases (GRKs) regulate seven-transmembrane receptors (7TMRs) by phosphorylating agonist-activated 7TMRs. Recently, we have reported that GRK2 can function as a negative regulator of insulin action by interfering with G pro
Publikováno v:
Molecular Endocrinology. 15:1864-1869
Insulin resistance, the failure to respond to normal circulating concentrations of insulin, is a common state associated with obesity, aging, and a sedentary lifestyle. Compelling evidence implicates TNFα as the cause and link between obesity and in
Autor:
Junko Kawahara, Tatsuhito Uno, Prem M. Sharma, Tetsuro Haruta, Katsuya Egawa, Atsuko Takano, Masashi Kobayashi, Jerrold M. Olefsky
Publikováno v:
Molecular Endocrinology. 14:783-794
Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology 2 domain containing signaling molecules that mediate many of the pleiotropic actions of insulin. Insulin stimulation elic
Publikováno v:
Molecular Endocrinology. 8:51-58
Chinese hamster ovary (CHO) cells were transfected with a cDNA encoding protein kinase C alpha (PKC) and a cell line (CHO-PKC alpha) expressing approximately 7-fold greater amounts of PKC as the parental cells were isolated. Activation of PKC by 12-O