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Autor:
Christian Sell
Publikováno v:
Molecular Endocrinology. 29:1107-1113
A remarkable plasticity in life span has been uncovered in recent years, offering hope that the basic mechanisms of aging and interventions that delay aging may be identified in the coming decades. Life span extension has been achieved by genetic man
Autor:
Raghavendra G. Mirmira, Medha Priyadarshini, Charles R. Mackay, Thierry Alquier, Annette Gilchrist, Helena Mancebo, Barton Wicksteed, Vincent Poitout, Miles Fuller, Stephanie R. Villa, Brian T. Layden
Publikováno v:
Molecular Endocrinology. 29:1055-1066
G protein-coupled receptors have been well described to contribute to the regulation of glucose-stimulated insulin secretion (GSIS). The short-chain fatty acid-sensing G protein-coupled receptor, free fatty acid receptor 2 (FFAR2), is expressed in pa
Autor:
Haochen Li, Thurl E. Harris, Chien Li, Hongxia Chao, Zhen Yan, Vitor A. Lira, Rebecca C. Grande
Publikováno v:
Molecular Endocrinology. 29:831-841
Type 2 corticotropin-releasing factor receptor (CRFR2) is expressed in skeletal muscle and stimulation of the receptor has been shown to inhibit the effect of insulin on glucose uptake in muscle cells. Currently, little is known about the mechanisms
Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Autor:
Peter D. Gluckman, Yung Seng Lee, Sudarsanareddy Lokireddy, Patnam Sreekanth, Radiance Lim, Hillary Chua, Tai E. Shyong, Craig McFarlane, Sabeera Bonala, Khoo Chin Meng, Ravi Kambadur, Jackie Ang, Mridula Sharma, Melvin Khee-Shing Leow, Marcus Lee
Publikováno v:
Molecular Endocrinology. 27:1518-1535
Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake. However, the mechanisms that interfere with insulin signaling and glucose uptake in human skeletal muscle during obesity are not fully characterized. Using m
Autor:
Patrick M. Sexton, Denise Wootten, Emilia Elizabeth Savage, Laurence J. Miller, Arthur Christopoulos, Cassandra Koole
Publikováno v:
Molecular Endocrinology. 27:1234-1244
The glucagon-like peptide-1 receptor (GLP-1R) controls the physiological responses to the incretin hormone glucagon-like peptide-1 and is a major therapeutic target for the treatment of type 2 diabetes, owing to the broad range of effects that are me
Autor:
Antonio Brunetti, Monica Fedele, Daniela Foti, Katiuscia Possidente, Eusebio Chiefari, Stefania Iiritano, Maria T. Nevolo, Valeria Ventura, Alfredo Fusco, Adelaide Greco, Aurora Nocera, Giuseppe Brunetti, Manfredi Greco, Biagio Arcidiacono
Publikováno v:
Molecular Endocrinology. 26:1578-1589
We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, causing a type 2-
Autor:
Ulrike Henrion, Martin Fraunholz, Behnam Hessabi, Robert Smail Jack, Annett Ostmann, Anke Karkour, Meike Dahlhaus, Piotr Grabarczyk, Reinhard Walther, Gabriele Wolf, Bernd Giese
Publikováno v:
Molecular Endocrinology. 24:2331-2342
The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element. To analyze the role of
Autor:
Norihiko Mori, Yoshiyuki Soeda, Naoki Toyooka, Xu Wang, Shuji Hosoh, Syota Kagawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Teruko Uwano, Hayato Muranaka, Yoshinori Ichihara, Yusaku Takamura, Tsutomu Wada, Hisao Nishijo
Publikováno v:
Molecular Endocrinology. 24:1965-1977
Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that
Autor:
Dongmei Wu, Alan J. Mears, Alexander Sorisky, Houssein Abdou Salem, Adèle Boudreau, Ella Atlas, Julianna J. Tomlinson, AnneMarie Gagnon, Robert J. G. Haché, Amanda Carrigan
Publikováno v:
Molecular Endocrinology. 24:104-113
Glucocorticoids are synthesized locally in adipose tissue and contribute to metabolic disease through the facilitation of adipose tissue expansion. Here we report that exposure of human primary preadipocytes to glucocorticoids increases their sensiti