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Autor:
Haochen Li, Thurl E. Harris, Chien Li, Hongxia Chao, Zhen Yan, Vitor A. Lira, Rebecca C. Grande
Publikováno v:
Molecular Endocrinology. 29:831-841
Type 2 corticotropin-releasing factor receptor (CRFR2) is expressed in skeletal muscle and stimulation of the receptor has been shown to inhibit the effect of insulin on glucose uptake in muscle cells. Currently, little is known about the mechanisms
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy
Autor:
E. Dale Abel, Adam R. Wende, Sandra Sena, Benjamin Wayment, Derek LeRoith, Heather A. Theobald, Crystal Sloan, Sheldon E. Litwin, Martin Holzenberger, Jaetaek Kim, Jamie Soto
Publikováno v:
Molecular Endocrinology. 22:2531-2543
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1R
Publikováno v:
Molecular Endocrinology. 21:2785-2794
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed to investigate the function of miRNAs in type 2 diabetes mellit
Autor:
Jennifer Rieusset, Silvia I. Anghel, Walter Wahli, Pierre Chambon, Daniel Metzger, Pascal Escher, Béatrice Desvergne, Liliane Michalik, Nguan Soon Tan, Josiane Seydoux
Publikováno v:
Molecular Endocrinology. 18:2363-2377
The peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in fat tissue development and physiology. Mutations in the gene encoding this receptor have been associated to disorders in lipid metabolism. A thorough investigation of mi
Publikováno v:
Molecular Endocrinology. 13:2013-2024
Caveolae may function as microdomains for signaling that help to determine specific biological actions mediated by the insulin receptor (IR). Caveolin-1, a major component of caveolae, contains a scaffolding domain (SD) that binds to a caveolin-1 bin
Autor:
Barry J. Goldstein, Alana L. Dudley
Publikováno v:
Molecular Endocrinology. 4:235-244
To investigate whether alterations in the polypeptide structure of the insulin receptor might explain the heterogeneity observed in its properties between species and in different tissues, we obtained the complete primary structure of the rat liver i