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Autor:
Herbert Y. Gaisano, Michael B. Wheeler, Youhou Kang, William S. Trimble, Laura Sheu, Xiaohang Huang, Gergely L. Lukacs
Publikováno v:
Molecular Endocrinology. 12:1060-1070
We and others have previously shown that insulin-secreting cells of the pancreas express high levels of SNAP-25 (synaptosomal-associated protein of 25 kDa), a 206-amino acid t-SNARE (target soluble N-ethylmaleimide-sensitive factor attachment protein
Publikováno v:
Molecular Endocrinology. 9:1468-1476
The most important regulator of insulin expression in islet beta-cells is glucose, which stimulates insulin gene transcription, protein synthesis, and secretion. Glucose-induced insulin gene transcription is regulated by cis-acting elements found wit
Publikováno v:
Molecular Endocrinology. 8:794-805
Insulin-like growth factor-binding protein-1 (IGFBP-1) modulates the action of IGFs on target cells. IGFBP-1 transcription is highly regulated by hormonal and metabolic factors. In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by de
Publikováno v:
Molecular Endocrinology. 7:1456-1462
Despite detailed knowledge of the regulation of individual steps in the gluconeogenic pathway, the relative importance of each step to the overall control of gluconeogenesis by insulin is not known. The aim of this study was to determine the role of
Autor:
Omar Pedro Pignataro, Mario Ascoli
Publikováno v:
Molecular Endocrinology. 4:758-765
In a recent publication we showed that addition of mouse epidermal growth factor (mEGF) to MA-10 Leydig tumor cells rapidly leads to an increase in the incorporation of [3H]inositol-derived radioactivity into an unusual lipid that was identified as p
Autor:
John W. Koontz, Patrick S. Moore
Publikováno v:
Molecular Endocrinology. 3:1724-1732
Tyrosine aminotransferase (TAT) is a liver-specific enzyme whose activity is subject to positive regulation by several agents including insulin and agonists that increase the intracellular concentration of cAMP. To further characterize the mechanism
Publikováno v:
Molecular Endocrinology. 1:569-576
Expression of the endogenous human GH (hGH) gene in response to glucocorticoids, thyroid hormone, and insulin was studied in cultures of dispersed GH-secreting human pituitary adenomas. Results were compared to those obtained when the hGH gene was tr
Publikováno v:
Molecular Endocrinology. 3:1215-1222
We demonstrate the differential sensitivity of poorly differentiated and well differentiated human colon carcinoma cells to nutrients alone or to nutrients and polypeptide growth factors under completely serum-free conditions. 3H-Thymidine incorporat
Publikováno v:
Molecular Endocrinology. 3:552-558
In MCF7 human breast cancer cells, cathepsin-D and pS2 mRNAs are specifically and directly induced by estrogens at the transcriptional level. We studied the regulation of expression of these two genes by growth factors that are also mitogenic in this