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Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Publikováno v:
Molecular Endocrinology. 20:844-856
We have identified Kruppel-like factor 7 (KLF7) as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of KLF7 in the pathogenesis of type 2 diabetes, we examined the functional roles of KLF7 in var
Publikováno v:
Molecular Endocrinology. 18:1670-1686
Previous studies have shown that the synthesis and stability of milk protein mRNAs are regulated by lactogenic hormones. We demonstrate here in cultured mouse mammary epithelial cells (CID 9) that insulin plus prolactin also synergistically increases
Autor:
Wolfgang Schmid, Christoph Kellendonk, Christian Opherk, Andreas Schulze, François Tronche, Günther Schütz, Dirk Kohlmüller
Publikováno v:
Molecular Endocrinology. 18:1346-1353
Hepatic glucose production by gluconeogenesis is the main source of glucose during fasting and contributes significantly to hyperglycemia in diabetes mellitus. Accordingly, glucose metabolism is tightly controlled by a variety of hormones including i
Autor:
Maribel Rios, Joseph Kelly, Guoping Fan, Rudolf Jaenisch, Brian Bates, Ronald M. Lechan, Ralf Kuehn, Csaba Fekete
Publikováno v:
Molecular Endocrinology. 15:1748-1757
Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role of this neurotrophin in weight regulation, we have generated conditional mutants in which brain-derived neurotrophic facto
Publikováno v:
Molecular Endocrinology. 12:825-834
Insulin-like growth factor I (IGF-I)/insulin induced cytosolic p42/p44 mitogen-activated protein kinase (MAPK) activation in a time-dependent manner in fetal brown adipocytes, reaching a maximum at 5 min. Concurrently, nuclear p42/p44 MAPKs were also
Publikováno v:
Molecular Endocrinology. 10:622-630
Insulin-dependent diabetes mellitus is associated with decreased levels of circulating insulin-like growth factor binding protein-3 (IGFBP-3), which are restored toward normal by treatment with insulin and/or infusion of insulin-like growth factor-I
Publikováno v:
Molecular Endocrinology. 9:1468-1476
The most important regulator of insulin expression in islet beta-cells is glucose, which stimulates insulin gene transcription, protein synthesis, and secretion. Glucose-induced insulin gene transcription is regulated by cis-acting elements found wit
Publikováno v:
Molecular Endocrinology. 8:794-805
Insulin-like growth factor-binding protein-1 (IGFBP-1) modulates the action of IGFs on target cells. IGFBP-1 transcription is highly regulated by hormonal and metabolic factors. In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by de