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Autor:
Karen L. Chen, Sarah Li, Yiru Chen Zhao, Alexander E. Lipka, Partha S. Ray, Eylem Kulkoyluoglu, Rebecca L. Smith, Tania Ray, Jamie N. Holloway, Kadriye Hieronymi, Yosef Landesman, Zeynep Madak-Erdogan, Kinga Wrobel
Publikováno v:
Molecular Endocrinology
Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be re
Autor:
Bert W. O'Malley
Publikováno v:
Molecular Endocrinology. 30:1015-1018
Autor:
Shingo Arakawa, Masahiko Negishi, Shogo Takahashi, Tatsuya Sueyoshi, Frank J. Gonzalez, Takuyu Hashiguchi
Publikováno v:
Molecular Endocrinology. 30:1070-1080
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either d
Publikováno v:
Molecular Endocrinology. 30:977-987
For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. He
Publikováno v:
Molecular Endocrinology. 30:905-916
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in perman
Autor:
Cheryl L. Walker, Mario Medvedovic, Shuk-Mei Ho, Rebecca Lee Yean Wong, Cristian Coarfa, Ali Shilatifard, Lindsey S. Treviño, Bert W. O’Malley, Jing Chen, Jianjun Shen, Quan Wang, Charles E. Foulds
Publikováno v:
Molecular Endocrinology. 30:856-871
Tissue and organ development is a time of exquisite sensitivity to environmental exposures, which can reprogram developing tissues to increase susceptibility to adult diseases, including cancer. In the developing prostate, even brief exposure to endo
Publikováno v:
Molecular Endocrinology. 30:917-924
Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of diabetes and the associated β-cell apoptosis. Although microRNAs (miRNAs) have been widely studied in various diseases including diabetes, the role of miRNAs in ER stre
Autor:
Cheryl L. Walker
Publikováno v:
Molecular Endocrinology. 30:848-855
The epigenome undergoes significant remodeling during tissue and organ development, which coincides with a period of exquisite sensitivity to environmental exposures. In the case of endocrine-disrupting compounds (EDCs), exposures can reprogram the e
Autor:
Lutz Schomburg, Josef Köhrle, Laura Kalveram, Annette Grüters-Kieslich, Heike Biebermann, Mariusz W. Szkudlinski, Gunnar Kleinau
Publikováno v:
Molecular Endocrinology. 30:954-964
Naturally occurring thyrotropin (TSH) mutations are rare, which is also the case for the homologous heterodimeric glycoprotein hormones (GPHs) follitropin (FSH), lutropin (LH), and choriogonadotropin (CG). Patients with TSH-inactivating mutations pre
Publikováno v:
Molecular Endocrinology. 30:614-629
GPR119 is a G protein-coupled receptor expressed on intestinal L cells that synthesize and secrete the blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1). GPR119 agonists stimulate the release of GLP-1 from L cells, and for this reason th