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Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Autor:
Kathryn B. Horwitz
Publikováno v:
Molecular Endocrinology. 22:2743-2750
This transcript is based on my The Year in Basic Science lecture at ENDO 2008. I reviewed current data surrounding hormone replacement therapy and the relationship between systemic estrogen plus progestin (E+P) treatment and increased breast cancer r
Autor:
Suzanne D. Conzen
Publikováno v:
Molecular Endocrinology. 22:2215-2228
Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been largely limited to estrogen and progesterone receptors. The development of reliable gene expression arrays, real-time quantitative RT-PCR, and immunohistoch
Autor:
Shuyun Rao, Joanne M. Faysal, Carol A. Maiorino, Wayne Balkan, Leah S. Lyons, Kerry L. Burnstein
Publikováno v:
Molecular Endocrinology. 22:597-608
Prostate cancer invariably recurs after androgen deprivation therapy. Growth of this recurrent/androgen-independent form of prostate cancer may be due to increased androgen receptor (AR) transcriptional activity in the absence of androgen. This ligan
Autor:
Sujit S. Nair, Darrell W Brann, Dujin Zhou, Rajib Rajhans, Valerie Cortez, Hareesh B. Nair, Ratna K. Vadlamudi, Nameer B. Kirma, Alan E.C. Holden, Kijima Ikuko, Rajeshwar Rao Tekmal, Shiuan Chen
Publikováno v:
Molecular Endocrinology. 22:649-664
In situ estrogen synthesis is implicated in tumor cell proliferation through autocrine or paracrine mechanisms especially in postmenopausal women. Several recent studies demonstrated activity of aromatase, an enzyme that plays a critical role in estr
Publikováno v:
Molecular Endocrinology. 22:273-286
Increased androgen receptor (AR) levels are associated with prostate cancer progression to androgen independence and therapy resistance. Evidence has suggested that chronic inflammation is closely linked to various cancers including prostate cancer.
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Publikováno v:
Molecular Endocrinology. 21:2785-2794
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed to investigate the function of miRNAs in type 2 diabetes mellit
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Autor:
Frank A. Simmen, Thomas M. Badger, Ling He, John C. Marecki, Ginette Serrero, Martin J. J. Ronis
Publikováno v:
Molecular Endocrinology. 21:2541-2550
Routine consumption of alcohol at low doses is associated with decreased risk of acquiring type 2 diabetes, whereas chronic and excessive alcohol consumption increases the risk. Although there is good epidemiologic evidence for these biphasic effects