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Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav
Autor:
Donald K. Scott, J. Jason Collier
Publikováno v:
Molecular Endocrinology. 18:1051-1063
The liver is responsible for glucose synthesis in the fasting state, and glucose uptake, storage, and utilization in the fed state. A phenotypic switch, normally initiated by insulin or glucagon, controls the transition between the two states, which
Autor:
Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski
Publikováno v:
Molecular Endocrinology. 17:93-106
Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin se
Autor:
Inkyu Lee, Min Hu, Li Wang, Jiansheng Huang, Pradip K. Saha, Yong-Deuk Kim, Keun-Gyu Park, David D. Moore, Rohit N. Kulkarni, Arun S. Rajan, Lawrence Chan
Publikováno v:
Molecular Endocrinology. 22:2203-2203
The orphan receptor small heterodimer partner (SHP; NROB2) is a transcriptional repressor that inhibits nuclear receptor signaling in diverse metabolic pathways. Here, we report that SHP(-/-) mice exhibited hypoinsulinemia with age, which was associa