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Autor:
Lakshmanan K. Iyer, Thomas Westerling, Francesca E. Gordon, Gavin R. Schnitzler, Myles Brown, Caroline S. Vallaster
Publikováno v:
Molecular Endocrinology. 28:1337-1351
Estrogen has vascular protective effects in premenopausal women and in women younger than 60 years who are receiving hormone replacement therapy. However, estrogen also increases the risks of breast and uterine cancers and of venous thromboses linked
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Publikováno v:
Molecular Endocrinology. 15:1993-2009
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expre
Autor:
Indrani C. Bagchi, Padmaja Ganapathy, Xueping Xu, Dahu Chen, Milan K. Bagchi, Li-Ji Zhu, Quanxi Li
Publikováno v:
Molecular Endocrinology. 13:993-1004
The steroid hormone estrogen profoundly influences the early events in the uterus leading to embryo implantation. It is thought that estrogen triggers the expression of a unique set of genes in the preimplantation endometrium that in turn control imp
Publikováno v:
Molecular Endocrinology. 11:801-811
A combination of a knockout mouse model, tissue transplantation, and gene expression analysis has been used to investigate the role of steroid hormones in mammary gland development. Mouse mammary gland development was examined in progesterone recepto
Autor:
Diane M. Robins, Stefanie A. Nelson
Publikováno v:
Molecular Endocrinology. 11:460-469
The mouse sex-limited protein (Slp) gene is expressed in liver and kidney of adult males and is testosterone-inducible in females, indicative of androgen dependence. Analysis of mRNA levels and chromatin configuration reveals that this androgen regul
Publikováno v:
Molecular Endocrinology. 9:691-705
A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 diff
Publikováno v:
Molecular Endocrinology. 8:782-793
The role of testosterone (T) and 17 beta-estradiol (E2) in the control of chinook salmon gonadotropin II beta subunit (sGTHII beta) gene was examined. Both E2 and T specifically stimulated GTHII beta gene expression in cultured juvenile rainbow trout
Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen
Publikováno v:
Molecular Endocrinology. 7:924-936
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work, the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breas
Autor:
Malcolm J. Low, T R Kumar
Publikováno v:
Molecular Endocrinology. 7:898-906
Transgenic mice that express a 10-kilobase human FSH beta (hFSH beta) gene exclusively in pituitary gonadotropes were used to study the regulation of hFSH beta gene expression by gonadal steroids. For comparison, the mouse FSH beta (mFSH beta) gene w