Zobrazeno 1 - 10
of 14
pro vyhledávání: ''
Autor:
Lakshmanan K. Iyer, Thomas Westerling, Francesca E. Gordon, Gavin R. Schnitzler, Myles Brown, Caroline S. Vallaster
Publikováno v:
Molecular Endocrinology. 28:1337-1351
Estrogen has vascular protective effects in premenopausal women and in women younger than 60 years who are receiving hormone replacement therapy. However, estrogen also increases the risks of breast and uterine cancers and of venous thromboses linked
Autor:
Erik C. Rocheford, Tara L. Mullarkey, Nico Mitro, Xue Li, Enrique Saez, Patrick Kennedy, S. Renee Commerford, Leo Vargas, Puiying A. Mak, Suzanne E. Dorfman
Publikováno v:
Molecular Endocrinology. 21:3002-3012
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with synthetic LXR ligands enhances glucose tolerance, inducing changes in gene expression expected
Autor:
Diane M. Robins, Stefanie A. Nelson
Publikováno v:
Molecular Endocrinology. 11:460-469
The mouse sex-limited protein (Slp) gene is expressed in liver and kidney of adult males and is testosterone-inducible in females, indicative of androgen dependence. Analysis of mRNA levels and chromatin configuration reveals that this androgen regul
Publikováno v:
Molecular Endocrinology. 10:622-630
Insulin-dependent diabetes mellitus is associated with decreased levels of circulating insulin-like growth factor binding protein-3 (IGFBP-3), which are restored toward normal by treatment with insulin and/or infusion of insulin-like growth factor-I
Publikováno v:
Molecular Endocrinology. 6:2219-2228
Insulin-like growth factor-binding protein-1 (IGFBP-1) can inhibit or potentiate IGF action. The biological activity of IGFBP-1 is determined by many factors, including its abundance in tissues and plasma, posttranslational modifications, and localiz
Autor:
Lynn R. Carnaghi, Stephen J. Giddings
Publikováno v:
Molecular Endocrinology. 6:1665-1672
Insulin gene expression has been demonstrated in nonpancreatic tissues early in development, suggesting that this hormone might have actions significant for the differentiating embryo. Because such actions imply ligand-receptor binding, we quantified
Publikováno v:
Molecular Endocrinology. 4:1655-1660
We evaluated the role insulin plays in the regulation of hepatic S14 gene transcription using the streptozotocin-induced diabetic rat model. Nuclear run-on activity and mRNAS14 levels were reduced by more than 85% in diabetic rats compared to those i
Autor:
J. Schwander, Christoph Schmid, Ernst Rudolf Prof Dr Froesch, J Zapf, Peter J. Meier, J.-L. Mary, M. Boni-Schnetzler, B. Zimmerli
Publikováno v:
Molecular Endocrinology. 4:1320-1326
The goal of this study was to find out whether GH or insulin regulate the mRNA expression of the fetal binding protein of insulin-like growth factor (IGFBP-2). Primary hepatocytes from adult rats were used as a test system. IGFBP-2 mRNA was abundant
Publikováno v:
Molecular Endocrinology. 4:1199-1204
The low mol wt insulin-like growth factor-binding protein (IGFBP-1) originally isolated from amniotic fluid has been considered to be GH independent. In this report we have examined the effect of GH on hepatic IGFBP-1 expression in the hypophysectomi
Autor:
Maureen K. Steed, John A. Robertson, Timothy J. J. Wood, Jan-Ake Gustafsson, Lars Arne Haldosén
Publikováno v:
Molecular Endocrinology. 4:1235-1239
The female-specific expression of the rat liver PRL receptor (PRL-R) gene was investigated by Northern analysis of hypophysectomized rats after two alternative human GH treatments that were to mimic either 1) the continuous female-specific or 2) the