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Publikováno v:
Molecular Endocrinology. 29:1787-1791
Recently, several LH/human chorionic gonadotropin (hCG) receptor-independent activities for hCG have been described, including activation of the TGF-β receptor (TGFβR) by hyperglycosylated hCG and stimulation of trophoblast invasion. Because the hC
Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Autor:
Lakshmanan K. Iyer, Thomas Westerling, Francesca E. Gordon, Gavin R. Schnitzler, Myles Brown, Caroline S. Vallaster
Publikováno v:
Molecular Endocrinology. 28:1337-1351
Estrogen has vascular protective effects in premenopausal women and in women younger than 60 years who are receiving hormone replacement therapy. However, estrogen also increases the risks of breast and uterine cancers and of venous thromboses linked
Publikováno v:
Molecular Endocrinology. 28:406-417
Pancreatic β-cell death plays a role in both type 1 and type 2 diabetes, but clinical treatments that specifically target β-cell survival have not yet been developed. We have recently developed live-cell imaging-based, high-throughput screening met
Publikováno v:
Molecular Endocrinology. 28:197-207
Insulin, an established mitogen that promotes breast cancer cell growth, has been implicated in the link between obesity and an increased risk of breast cancer. However, the current understanding of signaling pathways that mediate the mitogenic actio
Autor:
Sandeep Pawar, Elina Starosvetsky, Indrani C. Bagchi, Milan K. Bagchi, Grant D. Orvis, Richard R. Behringer
Publikováno v:
Molecular Endocrinology. 27:1996-2012
Embryo implantation is regulated by a variety of endometrial factors, including cytokines, growth factors, and transcription factors. Earlier studies identified the leukemia inhibitory factor (LIF), a cytokine produced by uterine glands, as an essent
Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Alan J. Fox, Klaus H. Kaestner, Rana K. Gupta, Sebastian Rieck, Olga Smirnova, Peter White, Jonathan Schug, Philipp E. Scherer, Nan Gao, Mark P. Keller, Alan D. Attie, Zhao V. Wang
Publikováno v:
Molecular Endocrinology. 23:1702-1712
The inability of the ss-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, ss-cell replication is one of the mechanisms thought to cause the expansion of ss-cell mass. Efforts to treat diabete
Autor:
John McDonald, Anthony H. Taylor, Justin C. Konje, David G. Lambert, R. A. John Challiss, Paul J. Brighton, Jonathon M. Willets
Publikováno v:
Molecular Endocrinology. 23:1415-1427
Accumulating evidence highlights the importance of the endocannabinoid anandamide (AEA) as a key mediator in reproductive physiology. Current data suggest potential roles for AEA in gametogenesis, fertilization, and parturition. AEA exerts its action
Autor:
Suzanne D. Conzen
Publikováno v:
Molecular Endocrinology. 22:2215-2228
Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been largely limited to estrogen and progesterone receptors. The development of reliable gene expression arrays, real-time quantitative RT-PCR, and immunohistoch