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Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Elwood V. Jensen
Publikováno v:
Molecular Endocrinology. 19:1439-1442
In the 47 yr since the first evidence for a steroid hormone receptor was presented at an international congress to an audience of five persons, the concept of “alternative approach” has played an important role in providing new understanding. By
Publikováno v:
Molecular Endocrinology. 15:1993-2009
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expre
Autor:
Indrani C. Bagchi, Padmaja Ganapathy, Xueping Xu, Dahu Chen, Milan K. Bagchi, Li-Ji Zhu, Quanxi Li
Publikováno v:
Molecular Endocrinology. 13:993-1004
The steroid hormone estrogen profoundly influences the early events in the uterus leading to embryo implantation. It is thought that estrogen triggers the expression of a unique set of genes in the preimplantation endometrium that in turn control imp
Publikováno v:
Molecular Endocrinology. 11:801-811
A combination of a knockout mouse model, tissue transplantation, and gene expression analysis has been used to investigate the role of steroid hormones in mammary gland development. Mouse mammary gland development was examined in progesterone recepto
Autor:
Maria Slomczynska, Arun K. Roy, Chung S. Song, Tekmal R. Rao, W. F. Demyan, Song Her, Dong S. Kim, Bandana Chatterjee, Wolfgang Gallwitz
Publikováno v:
Molecular Endocrinology. 6:589-597
Mammalian estrogen sulfotransferase (EST; EC 2.8.2.4) sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3'-phosphate-5'-phosphosulfate. Sulfurylated steroids do not bind to the estrogen re
Publikováno v:
Molecular Endocrinology. 6:157-167
While steroid response is generally restricted by the availability of steroid receptors, the theoretical limits of the response are not known. We have constructed a series of cell lines that stably express the estrogen receptor (ER) at levels up to 5
Autor:
Christina A. Harrington, Mindy F. Rosenthal, Dona M. Chikaraishi, Joan I. Morrell, Joseph T. McCabe, Donald W. Pfaff
Publikováno v:
Molecular Endocrinology. 3:1426-1433
The dopamine-producing neurons of the tuberoinfundibular region are known targets of estrogen and progesterone, and are of considerable neuroendocrine importance. To determine the anatomical distribution, and number of cells that contain tyrosine hyd
Publikováno v:
Molecular Endocrinology. 3:295-304
Since sex steroid hormones and growth factors are known to modulate the proliferation of breast tumors, we have studied the effects of estrogen and progestin, their antagonists, and growth factors on the regulation of estrogen receptor (ER) mRNA and
Autor:
Nicholas Barden, A. Peiffer
Publikováno v:
Molecular Endocrinology. 1:435-440
Using Northern blots and hybridization techniques, we have identified an approximately 6.5 kilobase glucocorticoid receptor mRNA species in rat anterior pituitary gland. Ovariectomy resulted in an approximately 2-fold increase in glucocorticoid recep