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Autor:
Yuko Ishido, Aya Yoshihara, Donald F. Sellitti, Yuqian Luo, Akira Kawashima, Takeshi Akama, Akito Tanoue, Kazuaki Nakamura, Kazunari Tanigawa, Koichi Suzuki
Publikováno v:
Molecular Endocrinology. 28:368-379
Thyroglobulin (Tg), stored in the follicular lumen, has also been shown recently to perform two unexpected roles: as an autocrine negative-feedback suppressor of thyroid function in the presence of TSH and as a potent inducer of thyroid cell growth i
Autor:
Helmut Grasberger, Marc Abramowicz, Paule LeFrancois, Samuel Refetoff, Usanee Ringkananont, Gilbert Vassart
Publikováno v:
Molecular Endocrinology. 19:1779-1791
Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family. The
Autor:
Jacques Emile Dumont, Bernard Corvilain, Ling Jin, Catherine Ledent, Paul Van Hummelen, Hortensia Mircescu, Jean-Christophe Goffard
Publikováno v:
Molecular Endocrinology. 18:194-213
Mutations of the TSH receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and nonautoimmune hyperthyroidism, when occurring in a germinal cell. An animal mod
Publikováno v:
Molecular Endocrinology. 15:1829-1837
The 39-44 kDa protein known as the receptor-associated protein binds to members of the low density lipoprotein receptor family and is found within cells that express these receptors. The receptor-associated protein has been shown to prevent premature
Publikováno v:
Molecular Endocrinology. 10:801-812
Thyroid-enriched transcription factors, Pax-8 and TTF-1, are involved in the thyroid-specific expression of thyroglobulin (TG) gene. Here we demonstrate redox regulation of both factors in vitro and in vivo. When analyzed by electrophoretic mobility
Publikováno v:
Molecular Endocrinology. 10:826-836
Interferon-gamma (IFN gamma) is known to suppress the expression of thyroid-specific genes, such as thyroglobulin, thyroid peroxidase, and the TSH receptor (TSHR). In the present study, we show that this reflects, in part, a transcriptional action me
Publikováno v:
Molecular Endocrinology. 7:1589-1595
The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid trans
Publikováno v:
Molecular Endocrinology. 6:1310-1317
The mechanism responsible for the stimulation of thyroglobulin (Tg) gene expression by insulin and insulin-like growth factor I (IGF-I) in rat thyroid FRTL-5 cells has been investigated. Both insulin and IGF-I stimulate transcription from the Tg prom
Publikováno v:
Molecular Endocrinology. 3:758-762
We have previously demonstrated that recombinant gamma-interferon (gamma IF) inhibits thyroid cell proliferation in vitro. We now demonstrate differential regulation of thyroid cell genes by recombinant gamma IF, as evidenced by data obtained measuri