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Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Autor:
Jacques Emile Dumont, Bernard Corvilain, Ling Jin, Catherine Ledent, Paul Van Hummelen, Hortensia Mircescu, Jean-Christophe Goffard
Publikováno v:
Molecular Endocrinology. 18:194-213
Mutations of the TSH receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and nonautoimmune hyperthyroidism, when occurring in a germinal cell. An animal mod
Publikováno v:
Molecular Endocrinology. 15:1880-1890
The hypothalamo-pituitary-adrenal (HPA) axis maintains a homeostatic response to stress, infection, or neoplasia. Inflammatory cytokines, including leukemia inhibitory factor (LIF), stimulate the HPA axis either directly at the pituitary corticotroph
Publikováno v:
Molecular Endocrinology. 14:1147-1161
Various mediators, including cytokines, growth factors, homeotic gene products, and prostaglandins (PGs), participate in the implantation process in an autocrine, paracrine, or juxtacrine manner. However, interactions among these factors that result
Publikováno v:
Molecular Endocrinology. 7:1589-1595
The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid trans
Autor:
Danielle Naville, Judith R. Head, J. Ian Mason, Diane S. Keeney, Graham Jenkin, Barbara A. Murry
Publikováno v:
Molecular Endocrinology. 5:1090-1100
In the steroidogenic pathways present in the gonads and adrenal cortex, 3 beta-hydroxysteroid dehydrogenase isomerase (3 beta HSD) is a key enzyme which controls the formation of delta 4-3-ketosteroids from delta 5-3 beta-hydroxysteroids. Herein, we
Publikováno v:
Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Molecular Endocrinology-Baltimore-, Endocrine Society, 1990, 4 (10), pp.1497-1505. ⟨10.1210/mend-4-10-1497⟩
Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pitu
Publikováno v:
Molecular Endocrinology. 4:583-588
Analysis of glucose transporter mRNA levels in adipose tissue from streptozotocin (STZ)-induced diabetic rats demonstrated a specific decrease (10-fold) in adipose tissue GLUT-4 mRNA with no significant effect on GLUT-1 mRNA levels. Treatment of STZ-
Publikováno v:
Molecular Endocrinology. 4:108-118
The gene encoding the opioid peptide precursor preproenkephalin is expressed at high levels in the initial segment of the adult rat epididymis. Expression is localized to principal cells, the secretory epithelial cells lining the epididymal duct. Dur