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Autor:
Erik C. Rocheford, Tara L. Mullarkey, Nico Mitro, Xue Li, Enrique Saez, Patrick Kennedy, S. Renee Commerford, Leo Vargas, Puiying A. Mak, Suzanne E. Dorfman
Publikováno v:
Molecular Endocrinology. 21:3002-3012
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with synthetic LXR ligands enhances glucose tolerance, inducing changes in gene expression expected
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Autor:
Ai Li Yeo, Peter Nowotny, Maria Nilsson, Edison T. Liu, Thomas M. Stulnig, Chin-Yo Lin, Knut R. Steffensen
Publikováno v:
Molecular Endocrinology. 21:126-137
The nuclear hormone receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Adr
Autor:
Helmut Grasberger, Marc Abramowicz, Paule LeFrancois, Samuel Refetoff, Usanee Ringkananont, Gilbert Vassart
Publikováno v:
Molecular Endocrinology. 19:1779-1791
Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family. The
Autor:
Sophie Giorgetti-Peraldi, Marie-Noëlle Monthouël-Kartmann, Joseph Murdaca, Emmanuel Van Obberghen, Caroline Treins
Publikováno v:
Molecular Endocrinology. 19:1304-1317
Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-inde
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Autor:
Minoru Asada, Yoel Sadovsky, Louis J. Muglia, Yoshihiko Nagai, Thomas J. Hudson, Kathleen E. Bethin, Robert Sladek
Publikováno v:
Molecular Endocrinology. 17:1454-1469
Improved care of infants born prematurely has increased their survival. However, the incidence of preterm labor has not changed. To understand the processes involved in preterm labor, we used oligonucleotide microarrays to study gene expression in mu
Autor:
Olivier Goupille, Andrew Ziemiecki, Wolfgang Doppler, Claudia Soratroi, Martin Tonko, Sibylle Tonko-Geymayer, Charles H. Streuli, Reinhard Kofler, Akihiko Yoshimura
Publikováno v:
Molecular Endocrinology. 16:1680-1695
The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal tr
Autor:
Nicos A. Nicola, Patrick Bertolino, Jason Corbin, Helen W. Davey, Douglas J. Hilton, Donald Metcalf, Sylvia L. Asa, Christopher J. Greenhalgh, Warren S. Alexander, Timothy E. Adams
Publikováno v:
Molecular Endocrinology. 16:1394-1406
Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the prod
Publikováno v:
Molecular Endocrinology. 15:1929-1940
Steroid hormone receptors and signal transducers and activators of transcription (STAT) factors constitute two distinct families of transcription factors activated by different signaling pathways. In previous reports, cross-talk between STAT5 and sev