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Publikováno v:
Molecular Endocrinology. 27:536-547
Plasma membrane cholesterol accumulation has been implicated in cellular insulin resistance. Given the role of the hexosamine biosynthesis pathway (HBP) as a sensor of nutrient excess, coupled to its involvement in the development of insulin resistan
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Autor:
Jennifer Rieusset, Silvia I. Anghel, Walter Wahli, Pierre Chambon, Daniel Metzger, Pascal Escher, Béatrice Desvergne, Liliane Michalik, Nguan Soon Tan, Josiane Seydoux
Publikováno v:
Molecular Endocrinology. 18:2363-2377
The peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in fat tissue development and physiology. Mutations in the gene encoding this receptor have been associated to disorders in lipid metabolism. A thorough investigation of mi
Autor:
Darryl L. Russell, JoAnne S. Richards
Publikováno v:
Molecular Endocrinology. 13:2049-2064
PRL activates an important cytokine signaling cascade that is obligatory for maintaining luteal cell function in the rat ovary. To determine when specific components of this cascade are expressed and can be activated by PRL, we analyzed the expressio
Autor:
Kelce Wr, Kathy Bobseine, Elizabeth Langley, Choi iok Wong, Elizabeth M. Wilson, Jon A. Kemppainen
Publikováno v:
Molecular Endocrinology. 13:440-454
Natural and pharmacological androgen receptor (AR) ligands were tested for their ability to induce the AR NH2-terminal and carboxyl-terminal (N/C) interaction in a two-hybrid protein assay to determine whether N/C complex formation distinguishes in v
Autor:
Diane M. Robins, Stefanie A. Nelson
Publikováno v:
Molecular Endocrinology. 11:460-469
The mouse sex-limited protein (Slp) gene is expressed in liver and kidney of adult males and is testosterone-inducible in females, indicative of androgen dependence. Analysis of mRNA levels and chromatin configuration reveals that this androgen regul
Publikováno v:
Molecular Endocrinology. 10:801-812
Thyroid-enriched transcription factors, Pax-8 and TTF-1, are involved in the thyroid-specific expression of thyroglobulin (TG) gene. Here we demonstrate redox regulation of both factors in vitro and in vivo. When analyzed by electrophoretic mobility
Publikováno v:
Molecular Endocrinology. 9:563-578
Unlike the steroid hormone receptors that bind their response elements as homodimers, thyroid hormone receptor (TRs) as well as retinoic acid receptors and several other receptors have been shown to require heterodimerization with retinoid X receptor
Publikováno v:
Molecular Endocrinology. 8:1798-1806
The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-
Publikováno v:
Molecular Endocrinology. 8:782-793
The role of testosterone (T) and 17 beta-estradiol (E2) in the control of chinook salmon gonadotropin II beta subunit (sGTHII beta) gene was examined. Both E2 and T specifically stimulated GTHII beta gene expression in cultured juvenile rainbow trout