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Publikováno v:
Molecular Endocrinology. 28:406-417
Pancreatic β-cell death plays a role in both type 1 and type 2 diabetes, but clinical treatments that specifically target β-cell survival have not yet been developed. We have recently developed live-cell imaging-based, high-throughput screening met
Autor:
Sandeep Pawar, Elina Starosvetsky, Indrani C. Bagchi, Milan K. Bagchi, Grant D. Orvis, Richard R. Behringer
Publikováno v:
Molecular Endocrinology. 27:1996-2012
Embryo implantation is regulated by a variety of endometrial factors, including cytokines, growth factors, and transcription factors. Earlier studies identified the leukemia inhibitory factor (LIF), a cytokine produced by uterine glands, as an essent
Autor:
Jonna Frasor, Sarah C. Baumgarten
Publikováno v:
Molecular Endocrinology. 26:360-371
Approximately 75% of breast tumors express the estrogen receptor (ER), and women with these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will fail ER-targeted therapies due to either de novo or acquired resistance
Autor:
Inez Rogatsky, Jamie R. Flammer
Publikováno v:
Molecular Endocrinology. 25:1075-1086
For decades, natural and synthetic glucocorticoids (GC) have been among the most commonly prescribed classes of immunomodulatory drugs. Their unsurpassed immunosuppressive and antiinflammatory activity along with cost-effectiveness makes these compou
Publikováno v:
Molecular Endocrinology. 25:611-620
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epitheli
Publikováno v:
Molecular Endocrinology. 22:273-286
Increased androgen receptor (AR) levels are associated with prostate cancer progression to androgen independence and therapy resistance. Evidence has suggested that chronic inflammation is closely linked to various cancers including prostate cancer.
Publikováno v:
Molecular endocrinology (Baltimore Md.)
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids
Autor:
Alessandra K Cardozo, Joachim Størling, Daisy Crispim, Fernanda Ortis, Decio L. Eizirik, Thomas Mandrup-Poulsen
Publikováno v:
Molecular Endocrinology. 20:1867-1879
Cytokines, such as IL-1beta and TNF-alpha, contribute to pancreatic beta-cell death in type 1 diabetes mellitus. The transcription factor nuclear factor-kappaB (NF-kappaB) mediates cytokine-induced beta-cell apoptosis. Paradoxically, NF-kappaB has mo
Autor:
Jennifer Rieusset, Silvia I. Anghel, Walter Wahli, Pierre Chambon, Daniel Metzger, Pascal Escher, Béatrice Desvergne, Liliane Michalik, Nguan Soon Tan, Josiane Seydoux
Publikováno v:
Molecular Endocrinology. 18:2363-2377
The peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in fat tissue development and physiology. Mutations in the gene encoding this receptor have been associated to disorders in lipid metabolism. A thorough investigation of mi
Autor:
Julie M. Hall, Kenneth S. Korach
Publikováno v:
Molecular Endocrinology. 17:792-803
Recent clinical studies estimate that 60-70% of human ovarian and breast cancers overexpress the estrogen receptor (ER). However, despite the established mitogenic effects of estrogen in these tumors, proliferative markers of hormone action are limit