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Autor:
Jonna Frasor, Sarah C. Baumgarten
Publikováno v:
Molecular Endocrinology. 26:360-371
Approximately 75% of breast tumors express the estrogen receptor (ER), and women with these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will fail ER-targeted therapies due to either de novo or acquired resistance
Autor:
Inez Rogatsky, Jamie R. Flammer
Publikováno v:
Molecular Endocrinology. 25:1075-1086
For decades, natural and synthetic glucocorticoids (GC) have been among the most commonly prescribed classes of immunomodulatory drugs. Their unsurpassed immunosuppressive and antiinflammatory activity along with cost-effectiveness makes these compou
Publikováno v:
Molecular endocrinology (Baltimore Md.)
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids
Autor:
Leonard C. Harrison, Iain L. Campbell
Publikováno v:
Molecular Endocrinology. 2:1151-1156
Introduction The term lymphokine was introduced nearly 20 yr ago (1) to denote nonantibody, protein mediators of cellular immunity produced by activated lymphocytes. Monocyte products were subsequently termed monokines, but with the realization that