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Publikováno v:
Molecular Endocrinology. 5:1740-1747
We studied the effects of interleukin-1 alpha (IL-1) and tumor necrosis factor-alpha (TNF), alone and in combination, on MCF-7 breast cancer cells to determine whether these cytokines alter cell growth, TNF gene expression, and TNF secretion. We foun
Publikováno v:
Molecular Endocrinology. 5:1003-1012
A protein kinase capable of phosphorylating basic fibroblast growth factor (FGF) can be localized on the outer cell surface of human hepatoma cells (SK-Hep cells). The addition of [gamma-32P]ATP, but not H3(32)PO4, results in a rapid (less than 10 mi
Publikováno v:
Molecular Endocrinology. 4:1655-1660
We evaluated the role insulin plays in the regulation of hepatic S14 gene transcription using the streptozotocin-induced diabetic rat model. Nuclear run-on activity and mRNAS14 levels were reduced by more than 85% in diabetic rats compared to those i
Autor:
Susan E. Bates, Diane A. Bronzert, Martha R. Stampfer, Ralph K. Lindsey, Marc E. Lippman, James P. Sheridan, Eva M. Valverius, Robert B. Dickson
Publikováno v:
Molecular Endocrinology. 4:981-989
Platelet-derived growth factor (PDGF) is a potent mitogen in human serum which specifically stimulates the proliferation of mesenchymal cells. We have now examined normal human mammary epithelial cells (HMEC) derived from reduction mammaplasties and
Publikováno v:
Molecular Endocrinology. 1:339-347
Human fibroblasts, a cell type that is used extensively to determine the pleiotypic effects of the insulin-like growth factors, have been shown to secrete a 35K protein that binds somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) but not insuli
Publikováno v:
Molecular Endocrinology. 1:933-941
The effect of the glucocorticoid dexamethasone on the production and degradation of rat GH (rGH) cytoplasmic mRNA was studied in cultured rat pituitary tumor (GC) cells. The incorporation of [3H]uridine into both rGH cytoplasmic mRNA and the pyrimidi
Publikováno v:
Molecular Endocrinology. 3:1215-1222
We demonstrate the differential sensitivity of poorly differentiated and well differentiated human colon carcinoma cells to nutrients alone or to nutrients and polypeptide growth factors under completely serum-free conditions. 3H-Thymidine incorporat
Autor:
Donald B. Jump, Gerald J. Lepar
Publikováno v:
Molecular Endocrinology. 3:1207-1214
3T3-F442A cells differentiate from preadipocytes to adipocytes when cultured in medium containing fetal calf serum and insulin. We examined the regulation of the S14 gene in 3T3-F442A preadipocytes and adipocytes to determine whether these cells woul