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Publikováno v:
Molecular Endocrinology. 30:402-416
The arcuate nucleus of the hypothalamus represents a key center for the control of appetite and feeding through the regulation of 2 key neuronal populations, notably agouti-related peptide/neuropeptide Y and proopimelanocortin (POMC)/cocaine- and amp
Autor:
Chunxue Wang, Martin Egli, Michael R. Waterman, F. Peter Guengerich, Pradeep S. Pallan, Li Lei
Publikováno v:
Molecular Endocrinology. 29:1375-1384
Cytochrome P450 21A2 is a key player in steroid 21-hydroxylation and converts progesterone to 11-deoxycorticosterone and 17α-hydroxy progesterone to 11-deoxycortisol. More than 100 mutations in P450 21A2 have been established in patients thus far; t
Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Autor:
Catharine L. Smith, Vineela Kadiyala
Publikováno v:
Molecular Endocrinology. 28:607-621
Lysine deacetylases have been known to regulate nuclear receptor function for many years. In the unliganded state, nuclear receptors that form heterodimers with retinoid X receptors, such as the retinoic acid and thyroid hormone receptors, associate
Publikováno v:
Molecular Endocrinology. 28:406-417
Pancreatic β-cell death plays a role in both type 1 and type 2 diabetes, but clinical treatments that specifically target β-cell survival have not yet been developed. We have recently developed live-cell imaging-based, high-throughput screening met
Publikováno v:
Molecular Endocrinology. 28:197-207
Insulin, an established mitogen that promotes breast cancer cell growth, has been implicated in the link between obesity and an increased risk of breast cancer. However, the current understanding of signaling pathways that mediate the mitogenic actio
Publikováno v:
Molecular Endocrinology. 26:1339-1355
The proglucagon gene is expressed not only in the pancreas and intestine but also in the hypothalamus. Proglucagon-derived peptides have emerged as potential regulators of energy homeostasis. Whether leptin, insulin, or cAMP activation controls progl
Publikováno v:
Molecular Endocrinology. 25:2041-2053
Overexpression of steroid receptor coactivator (SRC)-1 and SRC-3 is associated with cancer initiation, metastasis, advanced disease, and resistance to chemotherapy. In most of these cases, SRC-1 and SRC-3 have been shown to promote tumor cell growth
Autor:
Christopher M. Henstridge, Nariman Balenga, Julia Kargl, Clara Andradas, Maria Waldhoer, Cristina Sánchez, Andrew J. Brown, Andrew J. Irving
Publikováno v:
Molecular Endocrinology. 25:1835-1848
Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a can
Publikováno v:
Molecular Endocrinology. 25:492-502
Acute insulin resistance is common after injury, infection, and critical illness. To investigate the role of reactive oxygen species (ROS) in critical illness diabetes, we measured hepatic ROS, which rapidly increased in mouse liver. Overexpression o