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Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Publikováno v:
Molecular Endocrinology. 20:844-856
We have identified Kruppel-like factor 7 (KLF7) as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of KLF7 in the pathogenesis of type 2 diabetes, we examined the functional roles of KLF7 in var
Publikováno v:
Molecular Endocrinology. 19:312-326
We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3′-k
Publikováno v:
Molecular Endocrinology. 13:1305-1317
Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone with powerful antidiabetogenic effects that are thought to be mediated by adenylyl cyclase (AC). Recently, we generated two GLP-1 receptor mutant isoforms (IC3-1 and DM-1) that displayed ef
Autor:
Herbert Y. Gaisano, Michael B. Wheeler, Youhou Kang, William S. Trimble, Laura Sheu, Xiaohang Huang, Gergely L. Lukacs
Publikováno v:
Molecular Endocrinology. 12:1060-1070
We and others have previously shown that insulin-secreting cells of the pancreas express high levels of SNAP-25 (synaptosomal-associated protein of 25 kDa), a 206-amino acid t-SNARE (target soluble N-ethylmaleimide-sensitive factor attachment protein
Autor:
Jerry L. Nadler, Runpei Wu, Swarup K. Chakrabarti, David A. Taylor-Fishwick, Kaiwen Ma, Craig S. Nunemaker
Publikováno v:
Molecular Endocrinology. 24:468-468
Context: Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs) produce active lipids that promote inflammatory damage by catalyzing the oxidation of linoleic and arachidonic acid, and LO
Publikováno v:
Molecular Endocrinology. 1:339-347
Human fibroblasts, a cell type that is used extensively to determine the pleiotypic effects of the insulin-like growth factors, have been shown to secrete a 35K protein that binds somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) but not insuli