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Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Publikováno v:
Molecular Endocrinology. 26:1339-1355
The proglucagon gene is expressed not only in the pancreas and intestine but also in the hypothalamus. Proglucagon-derived peptides have emerged as potential regulators of energy homeostasis. Whether leptin, insulin, or cAMP activation controls progl
Autor:
Shinichi Yamashita, Chawnshang Chang, Chih-Rong Shyr, Shuyuan Yeh, Kuo Pao Lai, Spencer Vitkus
Publikováno v:
Molecular Endocrinology. 26:52-66
Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior pros
Autor:
Norihiko Mori, Yoshiyuki Soeda, Naoki Toyooka, Xu Wang, Shuji Hosoh, Syota Kagawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Teruko Uwano, Hayato Muranaka, Yoshinori Ichihara, Yusaku Takamura, Tsutomu Wada, Hisao Nishijo
Publikováno v:
Molecular Endocrinology. 24:1965-1977
Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that
Autor:
Dongmei Wu, Alan J. Mears, Alexander Sorisky, Houssein Abdou Salem, Adèle Boudreau, Ella Atlas, Julianna J. Tomlinson, AnneMarie Gagnon, Robert J. G. Haché, Amanda Carrigan
Publikováno v:
Molecular Endocrinology. 24:104-113
Glucocorticoids are synthesized locally in adipose tissue and contribute to metabolic disease through the facilitation of adipose tissue expansion. Here we report that exposure of human primary preadipocytes to glucocorticoids increases their sensiti
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy
Autor:
E. Dale Abel, Adam R. Wende, Sandra Sena, Benjamin Wayment, Derek LeRoith, Heather A. Theobald, Crystal Sloan, Sheldon E. Litwin, Martin Holzenberger, Jaetaek Kim, Jamie Soto
Publikováno v:
Molecular Endocrinology. 22:2531-2543
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1R
Autor:
Alessandra K Cardozo, Joachim Størling, Daisy Crispim, Fernanda Ortis, Decio L. Eizirik, Thomas Mandrup-Poulsen
Publikováno v:
Molecular Endocrinology. 20:1867-1879
Cytokines, such as IL-1beta and TNF-alpha, contribute to pancreatic beta-cell death in type 1 diabetes mellitus. The transcription factor nuclear factor-kappaB (NF-kappaB) mediates cytokine-induced beta-cell apoptosis. Paradoxically, NF-kappaB has mo
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav