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Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav
Autor:
Mini P. Sajan, Michael Leitges, Mary L. Standaert, Uschi Braun, Friederike Kruse, Yoshinori Kanoh, Robert V. Farese, Atsushi Miura, Gautam Bandyopadhyay
Publikováno v:
Molecular Endocrinology. 18:373-383
Atypical protein kinase C (aPKC) isoforms have been suggested to mediate insulin effects on glucose transport in adipocytes and other cells. To more rigorously test this hypothesis, we generated mouse embryonic stem (ES) cells and ES-derived adipocyt
Autor:
Harumi Hattori, Koji Yoshimura, Cydney C. Brooks, Eleonora Presman, Yukio Fujisawa, Nozomi Katayama, Shigeya Kakimoto, Isao Kaieda, Paul F. Pilch, Hideaki Tojo
Publikováno v:
Molecular Endocrinology. 17:1216-1229
Insulin stimulates translocation of glucose transporter isoform type 4 (GLUT4) and the insulin-responsive aminopeptidase (IRAP) from an intracellular storage pool to the plasma membrane in muscle and fat cells. A role for the cytoskeleton in insulin
Autor:
Inkyu Lee, Min Hu, Li Wang, Jiansheng Huang, Pradip K. Saha, Yong-Deuk Kim, Keun-Gyu Park, David D. Moore, Rohit N. Kulkarni, Arun S. Rajan, Lawrence Chan
Publikováno v:
Molecular Endocrinology. 22:2203-2203
The orphan receptor small heterodimer partner (SHP; NROB2) is a transcriptional repressor that inhibits nuclear receptor signaling in diverse metabolic pathways. Here, we report that SHP(-/-) mice exhibited hypoinsulinemia with age, which was associa
Publikováno v:
Molecular Endocrinology. 3:1132-1141
In two cellular models of insulin resistance we measured glucose transport activity, total glucose transporter number using the cytochalasin B binding assay, and expression of a transporter mRNA species specifically hybridizing with cDNA cloned from